CAJ | 학술논문

目的分析2006~2011年来本院就诊泌尿生殖道感染者支原体检出及耐药率变化情况,为临床的诊断及治疗提供帮助.方法药敏试剂盒检测患者的泌尿生殖道分泌物,对解脲支原体(Uu)和人型支原体(Mh)分离、鉴定、计数,然后分析就诊患者的支原体培养及药敏试验结果.结果6年间检测疑似泌尿生殖道感染患者10997例,支原体阳性率为58.1%(6386/10997)；Uu 检出率为37.7%~48.3%,Mh 为0.3%~3.0%、混合型(Mh + Uu)为3.4%~18.6%.药敏试验结果表明：Uu对大环内酯类(红霉素、罗红霉素、阿奇霉素)敏感率变化非常显著,耐药率呈现上升趋势,对喹诺酮类(左氧氟沙星、氧氟沙星、环丙沙星)保持高度耐药.结论支原体感染已成为泌尿生殖道感染的主要病原体之一,其中Uu 感染占较大比例,同时支原体对大环内酯类、喹诺酮类药敏敏感性降低,提示临床应合理、规范用药,防止耐药菌株的产生及扩散.
목적분석2006~2011년래본원취진비뇨생식도감염자지원체검출급내약솔변화정황,위림상적진단급치료제공방조.방법약민시제합검측환자적비뇨생식도분비물,대해뇨지원체(Uu)화인형지원체(Mh)분리、감정、계수,연후분석취진환자적지원체배양급약민시험결과.결과6년간검측의사비뇨생식도감염환자10997례,지원체양성솔위58.1%(6386/10997)；Uu 검출솔위37.7%~48.3%,Mh 위0.3%~3.0%、혼합형(Mh + Uu)위3.4%~18.6%.약민시험결과표명：Uu대대배내지류(홍매소、라홍매소、아기매소)민감솔변화비상현저,내약솔정현상승추세,대규낙동류(좌양불사성、양불사성、배병사성)보지고도내약.결론지원체감염이성위비뇨생식도감염적주요병원체지일,기중Uu 감염점교대비례,동시지원체대대배내지류、규낙동류약민민감성강저,제시림상응합리、규범용약,방지내약균주적산생급확산.
Objective To analyze the infection rate and drug resistance of urinogenital mycoplasma in patients in our hospital from 2006 to 2011, so as to provide aid for clinical diagnosis and treatment . Methods The urogenital t ract secretions were detected by ureaplasma urealytium (Uu) and macoplasma hominics (Mh) susceptibility test kits. The mycoplasma culture and drug susceptibility test results were analyzed. Results The positive rate of mycoplasma was 58.1%(6386/10997) in a total of 10997 doubtful genitourinary infection samples during the six years ,in which 37.7%~48.3% was ureaplasma urealytium (Uu),0.3%~3.0% was macoplasma hominics (Mh), and 3.4%~18.6% was mixed infection (Uu and Mh). Susceptibility test showed that Ureaplasma urealytium was highly resistant to macrolides (erythromycin, roxithromycin , azithromycin),and the drug resistance displayed increasing tendency. Ureaplasma urealytium (Uu) kept highly resistant to quinolones (levofloxacin ,ofloxacin , ciprofloxacin). Conclusion Mycoplasma has become one of the main pathogens of urinogenital infection , most of which is ureaplasma urealytium (Uu). Meanwhile , drug resistance showed that mycoplasma was highly resistant against quinolones and macrolides. Antibiotics should be used cautiously to be used so as to prevent the accrescence of persisters.