CAJ | 학술논문

目的观察益赛普联合甲氨蝶呤(MTX)治疗活动性类风湿关节炎的临床疗效。方法将我院门诊或住院的47例类风湿关节炎患者随机分为试验组和对照组,试验组(24例),甲氨蝶呤每周定量口服1O~15mg 1次,联合益赛普50mg,每周皮下注射1次；对照组(23例),甲氨堞呤每周定量口服10~15mg 1次,疗程12周。以ACR20为主要评估指标,ACRS0及各具体观察指标为次要评估指标。结果益赛普联合甲氨蝶呤组治疗12周后,患者关节疼痛、关节肿胀明显减轻,晨僵时间明显缩短,类风湿因子、血沉、C-反应蛋白等指标改善均优于甲氨蝶呤组,不良反应少于甲氨蝶呤组。结论益赛普联合甲氨堞呤治疗活动性类风湿关节炎安全有效。明显优于甲氨蝶呤单治疗,值得临床推广。
목적관찰익새보연합갑안접령(MTX)치료활동성류풍습관절염적림상료효。방법장아원문진혹주원적47례류풍습관절염환자수궤분위시험조화대조조,시험조(24례),갑안접령매주정량구복1O~15mg 1차,연합익새보50mg,매주피하주사1차；대조조(23례),갑안첩령매주정량구복10~15mg 1차,료정12주。이ACR20위주요평고지표,ACRS0급각구체관찰지표위차요평고지표。결과익새보연합갑안접령조치료12주후,환자관절동통、관절종창명현감경,신강시간명현축단,류풍습인자、혈침、C-반응단백등지표개선균우우갑안접령조,불량반응소우갑안접령조。결론익새보연합갑안첩령치료활동성류풍습관절염안전유효。명현우우갑안접령단치료,치득림상추엄。
Objective To observe the effects of etanercept and methotrexate ( MTX ) in the treatment of active rheumatoid arthritis clinical curative effect. Methods hospital outpatient or hospitalization in47patients with rheumatoid arthritis were randomly divided into experimental group and control group, the test group (24cases), methotrexate weekly quantitative oral1O ~15mg1, the50mg weekly subcutaneous etanercept,1; control group (23cases), armor ammonia die tetrahydrobiopterin per week quantitative oral10~15mg 1times, for 12 weeks. With ACR20 as the main evaluation index, ACRS0 and the specific outcome measures as the main evaluation index. The results of etanercept combined with methotrexate group after 12 weeks of treatment, patients with joint pain, joint swelling significantly reduced, morning stiffness time was obviously shortened, rheumatoid factor, ESR, C reactive protein and other indicators were better than those with fewer side effects of methotrexate MTX group, group. Conclusion etanercept combined armor ammonia die in the treatment of active rheumatoid arthritis safe, effective. Methotrexate therapy was superior to single, worthy of clinical application.