CAJ | 학술논문

目的探讨PVA颗粒介入栓塞治疗非小细胞肺癌的临床疗效和毒副反应.方法选取中晚期非小细胞肺癌患者60例,随机分成两组,每组30例.A组采用PVA介入灌注栓塞治疗,B组仅行介入化疗灌注治疗.两组病例均在介入化疗灌注治疗1~2个疗程后进行临床疗效及毒副反应评价.结果 A组病例中卡氏评分提高占80%(16/20)； B组病例中卡氏评分提高占50%(10/20)( P <0.05).A组与B组病例的临床疗效分别为： CR 3.3%,0%；PR 70%,40%； SD 23.3%,50%； PD 3.3%,10%( P <0.05).A、B 两组6、12、18、24个月生存率分别为100%,90%；80%,65%；65%,40%；50%,25%,且毒副反应不增加.结论 PVA介入灌注栓塞治疗中晚期非小细胞肺癌疗效优于单纯介入化疗灌注治疗,且不增加毒副作用,是中晚期肺癌可选择的一种安全有效的治疗方法.
목적탐토PVA과립개입전새치료비소세포폐암적림상료효화독부반응.방법선취중만기비소세포폐암환자60례,수궤분성량조,매조30례.A조채용PVA개입관주전새치료,B조부행개입화료관주치료.량조병례균재개입화료관주치료1~2개료정후진행림상료효급독부반응평개.결과 A조병례중잡씨평분제고점80%(16/20)； B조병례중잡씨평분제고점50%(10/20)( P <0.05).A조여B조병례적림상료효분별위： CR 3.3%,0%；PR 70%,40%； SD 23.3%,50%； PD 3.3%,10%( P <0.05).A、B 량조6、12、18、24개월생존솔분별위100%,90%；80%,65%；65%,40%；50%,25%,차독부반응불증가.결론 PVA개입관주전새치료중만기비소세포폐암료효우우단순개입화료관주치료,차불증가독부작용,시중만기폐암가선택적일충안전유효적치료방법.
Objective To investigate the efficacy and side effects of transcatheter arterial PVA infusion embolization for mid and advanced non-small cell lung cancer(NSCLC). Methods: Sixty patients with advanced non-small cell lung cancer were randomly divided into two groups,with 30 each. Group A was treated with transcatheter arterial PVA infusion embolization, Group B was treated with interventional arterial infusion chemotherapy alone. Treatment response in both groups were evaluated as well as side effects after one or two cycles. Results:As to Group A, Karnofsky score had been improved in 16 cases, accounting for 80%(16/20);compared with 50%(10/20) in the Group B, there was significant difference(P<0.05).The immediate response of both groups after treatment were CR 3.3%,0%;PR 70%,40%; SD 23.3%,50%; PD 3.3%,10%, in group A vs. group B, respectively. There were significant differences (P <0.05). The survival rates of both groups for 6,12,18and 24 monthswere 100%,90%;80%,65%;65%,40%;50%,25%,respectively.Conclusions:The transcatheter arterial PVA infusion embolization of the intermediate and advanced NSCLC is more effective and without increasing side effect as compared to transcatheter arterial infusion chemotherapy alone.