CAJ | 학술논문

目的观察奈达铂联合替加氟治疗晚期食管癌的疗效和安全性，以供临床参考.方法选择我院2010年10月~2011年9月收治的晚期食管癌患者120例，随机分为两组各60例，均给予三维适形放疗.观察组患者同时给予奈达铂联合替加氟治疗.连续治疗6个疗程，观察临床疗效，并比较不良反应发生率的差异.结果与对照组比较，观察组总有效率明显较高，差异有统计学意义(p<0.05).两组患者不良反应发生率比较，差异无统计学意义(p>0.05).结论采用奈达铂联合替加氟治疗晚期食管癌可以取得良好的临床疗效，且不会增加不良反应，值得推广应用.
목적관찰내체박연합체가불치료만기식관암적료효화안전성，이공림상삼고.방법선택아원2010년10월~2011년9월수치적만기식관암환자120례，수궤분위량조각60례，균급여삼유괄형방료.관찰조환자동시급여내체박연합체가불치료.련속치료6개료정，관찰림상료효，병비교불량반응발생솔적차이.결과여대조조비교，관찰조총유효솔명현교고，차이유통계학의의(p<0.05).량조환자불량반응발생솔비교，차이무통계학의의(p>0.05).결론채용내체박연합체가불치료만기식관암가이취득량호적림상료효，차불회증가불량반응，치득추엄응용.
Objective To observe the Cha Naida platinum joint for the efficacy and safety of fluoride treatment of advanced esophageal cancer, for clinical reference. Method choose our hospital from October 2010 to September 2011 were 120 cases of advanced esophageal cancer patients were randomly divided into two groups of 60 cases, were given three-dimensional conformal radiotherapy. The patients at the same time give the the nedaplatin joint for fluoride treatment. Continuous treatment for six courses, clinical efficacy and compare adverse effects incidence difference. Results Compared with the control group, the observation group total efficiency is significantly higher, the difference was statistically significant (p <0.05). The incidence of adverse reactions of two groups of patients compared the difference was not statistically significant (p>0.05). Conclusion nedaplatin joint tegafur treatment of advanced esophageal cancer can achieve good clinical efficacy without increasing adverse reactions should be widely applied.