CAJ | 학술논문

目的比较氯氮平和氯氮平合并丙戊酸镁治疗难治性精神分裂症的疗效和不良反应.方法将72例难治性精神分裂症患者随机分为两组，分别应用氯氮平和氯氮平合并丙戊酸镁治疗8周.采用阳性和阴性症状量表(PANASS)和不良反应量表(TESS)评定疗效和不良反应.结果治疗结束时，两组PASS因子分值较治疗前均有明显降低，且具有统计学意义.氯氮平合并丙戊酸镁组阳性症状因子减分早于氯氮平组，且两组间有显著性差异(p<0.05).氯氮平合并丙戊酸镁组总有效率为75%，明显高于氯氮平组的47.1%(p<0.05).结论氯氮平合并丙戊酸镁治疗男性难治性精神分裂症疗效优于氯氮平.
목적비교록담평화록담평합병병무산미치료난치성정신분렬증적료효화불량반응.방법장72례난치성정신분렬증환자수궤분위량조，분별응용록담평화록담평합병병무산미치료8주.채용양성화음성증상량표(PANASS)화불량반응량표(TESS)평정료효화불량반응.결과치료결속시，량조PASS인자분치교치료전균유명현강저，차구유통계학의의.록담평합병병무산미조양성증상인자감분조우록담평조，차량조간유현저성차이(p<0.05).록담평합병병무산미조총유효솔위75%，명현고우록담평조적47.1%(p<0.05).결론록담평합병병무산미치료남성난치성정신분렬증료효우우록담평.
Objective To compare the efficacy and side-effects of clozapine with magnesium vaproate on patients with treatment –resistant schizophrenia.Methods Seventy two patients with treatment-resistant schizophrenia were rangdomly assigned to clozapine or clozapine unite magnesium vaproate treatment for 8 weeks.Efficacy and side effects were measured with PANSS and TESS..Results At the end of treatment ,each factor score of the two groups PANSS was reduced obviously compairing with that before the treatment Decreasing score of positive symptoms in clozapine unite magnesium vaproate group was earlier than that in clozapine group ,and there was statistiacal difference between the two groups (p<0.05).The overall effective rate of clozapine unite magnesium vaproate group (75%)was higher than that of clozapine group(47.1%)( p<0.05).Conclusion Clozapine unite magnesium valproate is superior to clozapine in the treatment-resistant schizophrenia.