CAJ | 학술논문

目的探讨血常规检测中血小板(PLT)计数及相关参数血小板平均体积(MPV)、血小板分布宽度(PDW)、大血小板比率(P-LCR)、血小板压积(PCT)在急性白血病中的疗效观察与预后判断,为临床诊治提供指导意义.方法选取急性白血病(AL)53例,采用Sysmex XE-5000全自动血细胞分析仪检测PLT、MPV、PDW、P-LCR、PCT,并与正常对照及治疗前后对比.结果初诊时AL的PLT、PCT和MPV明显低于正常对照组(P<0.01和<0.05),PDW、P-LCR差异无统计学意义(P>0.05).AL初诊与部分缓解组比较,PLT、PCT明显升高(P<0.05),MPV、PDW、P-LCR差异无统计学意义；与完全缓解组比较,PLT、PCT明显升高(P<0.01),MPV、P-LCR明显降低(P<0.05),PDW差异无统计学意义(P>0.05).结论血小板参数的检测对急性白血病的疗效观察与预后判断具有重要的临床意义.
목적탐토혈상규검측중혈소판(PLT)계수급상관삼수혈소판평균체적(MPV)、혈소판분포관도(PDW)、대혈소판비솔(P-LCR)、혈소판압적(PCT)재급성백혈병중적료효관찰여예후판단,위림상진치제공지도의의.방법선취급성백혈병(AL)53례,채용Sysmex XE-5000전자동혈세포분석의검측PLT、MPV、PDW、P-LCR、PCT,병여정상대조급치료전후대비.결과초진시AL적PLT、PCT화MPV명현저우정상대조조(P<0.01화<0.05),PDW、P-LCR차이무통계학의의(P>0.05).AL초진여부분완해조비교,PLT、PCT명현승고(P<0.05),MPV、PDW、P-LCR차이무통계학의의；여완전완해조비교,PLT、PCT명현승고(P<0.01),MPV、P-LCR명현강저(P<0.05),PDW차이무통계학의의(P>0.05).결론혈소판삼수적검측대급성백혈병적료효관찰여예후판단구유중요적림상의의.
AIM:To investigate the detection value of platelet parameters including platelet counts(PLT),platelet distribution width(PDW),mean platelet volume(MPV),platelet-large cell ratio(P-LCR) and plateletocrit(PCT) in acute leukemia(AL) to provide the guidance of clinical treatment.[METHODS]:A total of 53 patients with AL were studied. The platelet total(PLT),platelet distribution width(PDW),mean platelet volume(MPV),platelet-large cell ratio (P-LCR) and plateletocrit (PCT) were detected before and after treatment by Sysmex XE-5000 automated blood cell analyzer.The detection results before and after treatment were compared and statistically analyzed with healthy controls.[RESULTS]:There was no significant difference in MPV and P-LCR(P>0.05).PLT,MPV and PCT before treatment in AL group were significantly lower than that of healthy controls(P<0.01 and P<0.05),There was no significant difference in PDW and P-LCR(P>0.05).In addition,PLT and PCT in AL before treatment group were significantly lower than that of partial remission(PR)(P<0.05),there was no significant difference in MPV、PDW and P-LCR(P>0.05).PLT and PCT in AL before treatment group were significantly lower than that of complete remission(CR)(P<0.01),MPV and P-LCR in AL before treatment group were significantly higher than that of complete remission(CR)(P<0.05),and there was no significant difference in PDW(P>0.05).[CONCLUSION]:The platelet parameters could provide the important clinical information about treatment and prognosis of AL.