CAJ | 학술논문

目的探讨口腔粘膜恶性黑色素瘤临床治疗方法的效果.方法选取2005年8月至2010年2月我院收治的54例口腔粘膜恶性黑色素瘤作为研究对象.将54名患者随机分为两组,一组为单用手术治疗组,一组为手术联合免疫疗法治疗组.两组患者都进行手术切除治疗,而手术联合免疫疗法治疗组在此基础上还给予大剂量的卡介苗等免疫制剂进行联合治疗.根据分析所得出的结果,判断两组治疗方法的临床疗效.比较两组患者的治愈率及2年内存活率和3年内存活率.结果两组患者经治疗后,其口腔粘膜恶性黑色素瘤均得以消除,淋巴转移都有所控制,患者存活率也大大的提高,但手术联合免疫疗法组以92.59%的治愈率明显胜于单用手术治疗组59.26%的治愈率,差异有统计学意义(x2=8.2064,P<0.05).比较两组患者治疗后2年内存活率及3年内存活率,可得出手术联合免疫疗法组均明显高于单用手术组,差异有统计学意义(分别为4.9091,6.1346,P均<0.05).结论手术联合免疫疗法更适合于口腔粘膜恶性黑色素瘤,其疗效比单用手术治疗效果好.
목적탐토구강점막악성흑색소류림상치료방법적효과.방법선취2005년8월지2010년2월아원수치적54례구강점막악성흑색소류작위연구대상.장54명환자수궤분위량조,일조위단용수술치료조,일조위수술연합면역요법치료조.량조환자도진행수술절제치료,이수술연합면역요법치료조재차기출상환급여대제량적잡개묘등면역제제진행연합치료.근거분석소득출적결과,판단량조치료방법적림상료효.비교량조환자적치유솔급2년내존활솔화3년내존활솔.결과량조환자경치료후,기구강점막악성흑색소류균득이소제,림파전이도유소공제,환자존활솔야대대적제고,단수술연합면역요법조이92.59%적치유솔명현성우단용수술치료조59.26%적치유솔,차이유통계학의의(x2=8.2064,P<0.05).비교량조환자치료후2년내존활솔급3년내존활솔,가득출수술연합면역요법조균명현고우단용수술조,차이유통계학의의(분별위4.9091,6.1346,P균<0.05).결론수술연합면역요법경괄합우구강점막악성흑색소류,기료효비단용수술치료효과호.
Objective Effect of oral mucosal malignant melanoma clinical treatment effect. Method From 2005 August to 2010 February in our hospital 54 cases of oral mucosal malignant melanoma as research object.54 patients were randomly divided into two groups, one group for the single operation treatment group, a group of operation combined with immune therapy group.Two groups of patients were performed operation excision, and operation combined with immune therapy treatment group on the basis of this has given large doses of BCG and other immune agents combined therapy.According to the analysis of the obtained results, to judge the two groups of treatment clinical effect.Comparing the two groups of patients with the cure rate and survival rate of 2 years and 3 years survival rate. Result Two groups of patients after treatment, the oral mucosal malignant melanoma were eliminated, lymphatic metastasis have control, the survival rate of the patients is increased greatly, but the operation combined with immune therapy group with 92.59% cure rate was significantly better than single operation treatment group 59.26% cure rate, the difference was statistically significant (=8.2064, P<0.05).Comparison of two groups of patients after treatment with 2 years survival rate and 3 year survival rate, can obtain the operation combined with immune therapy group were significantly higher than that in single operation group, the difference was statistically significant (respectively 4.9091, 6.1346, P <0.05). Conclusion Operation combined with immune therapy is more suitable for oral mucosal malignant melanoma, its efficacy compared with the single operation cures effect well.