CAJ | 학술논문

目的探讨血必净注射液治疗糖尿病肾病的临床疗效及对血清IL-6、TNF-α的影响.方法60例糖尿病肾病患者随机分为治疗组30例，对照组30例.对照组以西医常规治疗为主，治疗组在西医常规治疗基础上联合血必净注射液静脉滴注，疗程为14天.观察治疗前后血肌酐(Cr)、尿素氮(BUN)及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平.结果治疗组总有效率优于对照组(P<0.05)，同时能有效降低Cr、BUN、IL-6、TNF-α(P<0.05).结论西医常规治疗联合血必净注射液治疗糖尿病肾病疗效优于单纯西医常规治疗，其可能的作用机制是降低血清中IL-6、TNF-α的水平，从而起到保护肾功能的作用.
목적탐토혈필정주사액치료당뇨병신병적림상료효급대혈청IL-6、TNF-α적영향.방법60례당뇨병신병환자수궤분위치료조30례，대조조30례.대조조이서의상규치료위주，치료조재서의상규치료기출상연합혈필정주사액정맥적주，료정위14천.관찰치료전후혈기항(Cr)、뇨소담(BUN)급백세포개소-6(IL-6)、종류배사인자-α(TNF-α)적수평.결과치료조총유효솔우우대조조(P<0.05)，동시능유효강저Cr、BUN、IL-6、TNF-α(P<0.05).결론서의상규치료연합혈필정주사액치료당뇨병신병료효우우단순서의상규치료，기가능적작용궤제시강저혈청중IL-6、TNF-α적수평，종이기도보호신공능적작용.
Objective To study the effect of Xuebijing injection on diabetic nephropathy and its affection on blood serum level of IL-6 and TNF-α. Methods Sixty patients with diabetic nephropathy were randomized into two groups:control group in which 30 cases were treated with primary therapy and treatment group in which 30 cases were treated with Xuebijing injection combined with primary therapy. Cr,BUN,IL-6,TNF-αin blood were detected before and after treatment. Results The total efficacy in treatment group was superior to control group(P<0.05). The blood level of Cr,BUN,IL-6,TNF-αin treatment group were decreased obviously(P<0.05). Conclusions Xuebijing injection combined with primary therapy was better than only primary therapy in treating diabetic nephropathy. It may protect kidney function from decreasing the blood level of IL-6 and TNF-α.