CAJ | 학술논문

目的观察加味补阳还五汤中药对奥沙利铂神经毒性的拮抗作用。方法对接受奥沙利铂化疗的98例肿瘤患者，分为治疗组和对照组。治疗组在应用奥沙利铂化疗的同时配合加味补阳还五汤中药治疗，对照组单用化疗。结果治疗组与对照组比较，两组临床疗效相似，但治疗组神经毒性的发生数以及发生程度明显低于对照组。结论加味补阳还五汤中药能有效的干预和拮抗奥沙利铂的神经毒性。
목적관찰가미보양환오탕중약대오사리박신경독성적길항작용。방법대접수오사리박화료적98례종류환자，분위치료조화대조조。치료조재응용오사리박화료적동시배합가미보양환오탕중약치료，대조조단용화료。결과치료조여대조조비교，량조림상료효상사，단치료조신경독성적발생수이급발생정도명현저우대조조。결론가미보양환오탕중약능유효적간예화길항오사리박적신경독성。
Objective To observe the antagonism of Chinese Medicine of BuYanghuanwutang to oxaliplatin neurotoxicity. Methods The 98 cases of cancer patients who accepted the oxaliplatin chemotherapy, divided into treatment and control groups. The treatment group accepted oxaliplatin chemotherapy combined with Chinese Medicine of Bu Yanghuanwutang, and the control groups only accepted oxaliplatin chemotherapy.Result The clinical effect may be similar in the treatment and control groups. But for the occurrence rate and degree of oxaliplatin neurotoxicity,the treatment groups is lower than control groups.Conclusions The Chinese Medicine of Bu Yanghuanwutang can intervene and antagonize the oxaliplatin neurotoxicity.