CAJ | 학술논문

目的探讨胃腺癌及癌旁组织中谷胱甘肽S-转移酶P1(glutathione S-transferase P1, GSTP1)表达水平及临床病理学意义.方法应用免疫组织化学方法检测75例原发性胃腺癌、38例癌旁正常组织石蜡标本中G S T P1蛋白表达水平,观察其与胃癌病人临床病理学参数的关系.结果 G S T P1在75例胃腺癌组织中有46例呈高表达；明显高于癌旁正常组织表达水平(x2=4.852,P=0.028), GSTP1表达与胃腺癌患者年龄、性别、肿瘤大小、浸润深度、分化程度及淋巴结转移均无明显相关性(P>0.05),但与患者预后相关(χ2=3.899,P=0.048).结论 GSTP1在胃腺癌中表达上调,并与胃腺癌患者预后相关.
목적탐토위선암급암방조직중곡광감태S-전이매P1(glutathione S-transferase P1, GSTP1)표체수평급림상병이학의의.방법응용면역조직화학방법검측75례원발성위선암、38례암방정상조직석사표본중G S T P1단백표체수평,관찰기여위암병인림상병이학삼수적관계.결과 G S T P1재75례위선암조직중유46례정고표체；명현고우암방정상조직표체수평(x2=4.852,P=0.028), GSTP1표체여위선암환자년령、성별、종류대소、침윤심도、분화정도급림파결전이균무명현상관성(P>0.05),단여환자예후상관(χ2=3.899,P=0.048).결론 GSTP1재위선암중표체상조,병여위선암환자예후상관.
Objective To study the clinicopathological significance of the expression of GSTP1 protein in gastric adenocarcinoma and adjacent non-cancerous gastric tissues. Methods The expression of GSTP1 protein in 75 gastric adenocarcinoma specimens and 38 adjacent non-cancerous gastric tissues were detected by immunohistochemistry. The relationship between the protein expression and clinicopathological features was analyzed. Results overexpression of GSTP1 protein was shown in 46 cases of gastric adenocarcinoma tissues, which was much higher than that in adjuvant non-cancerous gastric tissues (χ2=4.842,P=0.028). The expression of GSTP1 protein had no correlation with age, sex, tumor size, invasion depth, differentiation and Lymph node metastasis(P>0.05),but had statistic sig with the prognosis of the patients(χ2=3.899,P=0.048). Conclusion GSTP1 is up regulated in gastric adenocarcinoma and is related with the prognosis of the patients with gastric cancer.