CAJ | 학술논문

目的研究高原家兔胸部爆炸伤后血浆NO的变化特点.方法家兔随机分为高原致伤组,高原对照组和平原致伤组.分别于伤前和伤后1h、3h和6h各时间点检测各组血浆NO浓度.结果致伤前高原各组血浆NO浓度比平原组低(P<0.05),伤后各组NO浓度持续升高,A、C两组与伤前有明显差异(P<0.05),A组伤后各时间点NO的变化幅度明显高于C组(P<0.01).结论 NO可能是参与高原胸部爆炸伤后急性肺损伤过程的介质之一,这对于高原胸部爆炸伤的早期救治具有重要意义.
목적연구고원가토흉부폭작상후혈장NO적변화특점.방법가토수궤분위고원치상조,고원대조조화평원치상조.분별우상전화상후1h、3h화6h각시간점검측각조혈장NO농도.결과치상전고원각조혈장NO농도비평원조저(P<0.05),상후각조NO농도지속승고,A、C량조여상전유명현차이(P<0.05),A조상후각시간점NO적변화폭도명현고우C조(P<0.01).결론 NO가능시삼여고원흉부폭작상후급성폐손상과정적개질지일,저대우고원흉부폭작상적조기구치구유중요의의.
Objective To study the changes of NO in plasma after explosive injury of thorax in rabbits in high altitude. Methods Rabbits were randomly divided into control group in high altitude(group B), injury group in high altitude(group A) and injury group in plane(group C). Blood samples were collected before injury and at 1h, 3h, 6h after injury respectively for analysis of plasma NO. Results Before injury the plateau group of the plasma NO concentration was lower than the plain (P <0.05), NO concentration in each group after injury continues to rise, A, C groups were significantly different before injury (P <0.05), A group after injury NO changes at all time points rate was significantly higher than C group (P <0.01). Conclusion NO may be important mediators participating in the progress of lung injury after thoracic explosive injury in high altitude. This is the early treatment of thoracic blast injury is important.