CAJ | 학술논문

目的研究促血管生成素-2(Ang-2)在原发性肝癌组织中的表达及临床病理临床病理学的相关性.方法应用免疫组化ABC法分别检测35例肝癌组织、31例相应癌旁组织和10例正常肝脏组织中Ang-2的表达情况，并分析其临床病理学特征的相关性.结果Ang-2在正常肝组织中不表达，在肝癌组织中的阳性表达率明显高于癌旁组织和正常组织(P<0.05)；Ang-2在肝癌组织中的表达与病理分级、门静脉癌栓及淋巴结转移呈正相关(P<0.05)，但与患者的性别、年龄及肿瘤直径无相关性(P>0.05).结论 Ang-2在原发性肝癌中的高表达，其表达与病理学分级、门静脉癌栓及淋巴结转移呈正相关，提示其在原发性肝癌的发生、发展起一定作用.
목적연구촉혈관생성소-2(Ang-2)재원발성간암조직중적표체급림상병리림상병이학적상관성.방법응용면역조화ABC법분별검측35례간암조직、31례상응암방조직화10례정상간장조직중Ang-2적표체정황，병분석기림상병이학특정적상관성.결과Ang-2재정상간조직중불표체，재간암조직중적양성표체솔명현고우암방조직화정상조직(P<0.05)；Ang-2재간암조직중적표체여병리분급、문정맥암전급림파결전이정정상관(P<0.05)，단여환자적성별、년령급종류직경무상관성(P>0.05).결론 Ang-2재원발성간암중적고표체，기표체여병이학분급、문정맥암전급림파결전이정정상관，제시기재원발성간암적발생、발전기일정작용.
Objective To study the expression of Ang-2 in primary hepatocarcinoma(PHC)tissue and study of Clinicopathological. Methods: This investigation ABC will detected the expression of Ang-2 in 35 liver cancer specimens、31 liver corresponding paracarc inomas and 10 normal liver tissue slices by immunohistochemical staining and And then correlation among the clinical and pathological analysis . Results: Ang-2 protein was not expressed in normal tissues. The positive expression rate in PHC Significantly higher than normal tissue and adjacent noncancerous tissues, (P﹤0.05). Ang-2 expression in hepatocellular carcinoma it has significant correlation to the Pathological grading, tumor thrombus in portal-vein and lymph node metastasis(P﹤0.05), but it has no significant correlation to the patients' gender , age , tumor size (P﹥0.05). Conclusion: The high expression of Ang - 2 in primary liver cancer , is correlation to occurrence and development of primary hepatocarcinoma;Ang-2 expression in hepatocellular carcinoma it has positive correlation to the Pathological grading, tumor thrombus in portal-vein and lymph node metastasis