CAJ | 학술논문

目的：探讨氟伐他汀、贝那普利单用及联用对稳定型心绞痛血浆同型半胱氨酸的影响。方法选择该院门诊及住院稳定型心绞痛患者血浆HCY>15μmol/L 的120例患者,随机分为4组,常规治疗组：阿司匹林+硝酸酯类药；氟伐他汀组：氟伐他汀(40 mg ,1次/d)+常规治疗；贝那普利组：贝那普利(10 mg ,1次/d)+常规治疗；联合治疗组：氟伐他汀(40 mg，1次/d)+贝那普利(10 mg ,1次/d)+常规治疗。治疗3个月后再次测定检测HCY。结果①血浆HCY>15μmol/L 120例稳定型心绞痛患者中经治疗后，常规治疗组治疗前后差异无统计学意义( P>0.05)；氟伐他汀组、贝那普利组、联合治疗组治疗后血浆HCY水平显著降低,差异有统计学意义( P<0.01)；②氟伐他汀组与贝那普利组比较，差异无统计学意义(P>0.05)；③联合治疗组与氟伐他汀组、贝那普利组比较，差异有统计学意义(P<0.01)。结论氟伐他汀和贝那普利具有协同作用，两者都有降低稳定型心绞痛患者血浆中HCY水平的效能。
목적：탐토불벌타정、패나보리단용급련용대은정형심교통혈장동형반광안산적영향。방법선택해원문진급주원은정형심교통환자혈장HCY>15μmol/L 적120례환자,수궤분위4조,상규치료조：아사필림+초산지류약；불벌타정조：불벌타정(40 mg ,1차/d)+상규치료；패나보리조：패나보리(10 mg ,1차/d)+상규치료；연합치료조：불벌타정(40 mg，1차/d)+패나보리(10 mg ,1차/d)+상규치료。치료3개월후재차측정검측HCY。결과①혈장HCY>15μmol/L 120례은정형심교통환자중경치료후，상규치료조치료전후차이무통계학의의( P>0.05)；불벌타정조、패나보리조、연합치료조치료후혈장HCY수평현저강저,차이유통계학의의( P<0.01)；②불벌타정조여패나보리조비교，차이무통계학의의(P>0.05)；③연합치료조여불벌타정조、패나보리조비교，차이유통계학의의(P<0.01)。결론불벌타정화패나보리구유협동작용，량자도유강저은정형심교통환자혈장중HCY수평적효능。
Objective To observe the effect of fluvastatin and benazepril used alone and used in combination on the plasma homo-cysteine of patients with stable angina pectoris. Methods 120 cases of outpatients and inpatients with stable angina pectoris and plasma HCY> 15μmol/ L in our hospital were selected and randomly divided into 4 groups, the conventional treatment group: as-pirin+nitrates drugs;fluvastatin group:fluvastatin (40 mg, qd ) plus conventional therapy;benazepril group:benazepril (10 mg, qd ) plus conventional therapy;combination therapy group:fluvastatin (40 mg, qd)+benazepril (10mg, qd ) plus conventional therapy. HCY was detected again after 3 months of treatment. Results ① After the treatment, of the 120 patients with stable angina pec-toris and plasma HCY>15μmol/L, the plasma HCY level of the conventional treatment group before and after treatment showed no statistically significant difference (P>0.05);the plasma HCY level of fluvastatin group, benazepril group and the combination thera-py group decreased significantly after treatment, compared with that before the treatment, the difference was statistically significant (P<0.01);②the difference between fluvastatin group and benazepril group was not statistically significant (P>0.05);④ the differ-ence between the combination therapy group, fluvastatin group and benazepril group was statistically significant (P<0.01). Conclu-sion Fluvastatin and benazepril have a synergistic effect, both can reduce the plasma HCY levels of patients with stable angina pectoris.