现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
7期
988-989
,共2页
胆汁淤积,肝内%S-腺苷甲硫氨酸/治疗应用%熊脱氧胆酸/治疗应用%瘙痒症/并发症%思美泰%优思弗%妊娠期肝内胆汁淤积症
膽汁淤積,肝內%S-腺苷甲硫氨痠/治療應用%熊脫氧膽痠/治療應用%瘙癢癥/併髮癥%思美泰%優思弗%妊娠期肝內膽汁淤積癥
담즙어적,간내%S-선감갑류안산/치료응용%웅탈양담산/치료응용%소양증/병발증%사미태%우사불%임신기간내담즙어적증
Cholestasis,intrahepatic%S-Adenosylmethionine/therapeutic use%Ursodeoxycholic acid/therapeutic use%Pruritus/complications%Transmetil%Ursodeoxycholic acid%Intrahepatic cholestasis of pregnancy
目的：观察思美泰（丁二磺酸腺苷蛋氨酸）和优思弗（熊去氧胆酸）联合用药与思美泰单用治疗妊娠期肝内胆汁淤积症（ICP）的疗效。方法选取2010年1月至2013年1月收治的78例ICP患者，分成对照组和治疗组各39例。对照组给予思美泰治疗，治疗组给予思美泰联合优思弗治疗，14 d为1个疗程。对两组患者瘙痒症状改善情况、孕周、肝功能指标的改善进行比较。结果两组患者治疗后皮肤瘙痒情况明显好转，与治疗前比较，差异有统计学意义（P＜0.05）；治疗组治疗后较对照组评分低，差异有统计学意义（P＜0.05）；治疗组治疗后孕周[（36.3±0.11）周]较对照组[（34.2±0.17）周]明显延长，差异有统计学意义（P＜0.05）；两组患者治疗后总胆红素（TBIL）、胆汁酸（TBA）、丙氨酸氨基转移酶（ALT）水平均有所下降，与治疗前比较，差异有统计学意义（P＜0.05）；且治疗组治疗后TBIL、TBA、ALT水平较对照组下降更明显，差异有统计学意义（P＜0.05）。结论思美泰和优思弗联合用药治疗ICP较单用思美泰疗效更显著。
目的：觀察思美泰（丁二磺痠腺苷蛋氨痠）和優思弗（熊去氧膽痠）聯閤用藥與思美泰單用治療妊娠期肝內膽汁淤積癥（ICP）的療效。方法選取2010年1月至2013年1月收治的78例ICP患者，分成對照組和治療組各39例。對照組給予思美泰治療，治療組給予思美泰聯閤優思弗治療，14 d為1箇療程。對兩組患者瘙癢癥狀改善情況、孕週、肝功能指標的改善進行比較。結果兩組患者治療後皮膚瘙癢情況明顯好轉，與治療前比較，差異有統計學意義（P＜0.05）；治療組治療後較對照組評分低，差異有統計學意義（P＜0.05）；治療組治療後孕週[（36.3±0.11）週]較對照組[（34.2±0.17）週]明顯延長，差異有統計學意義（P＜0.05）；兩組患者治療後總膽紅素（TBIL）、膽汁痠（TBA）、丙氨痠氨基轉移酶（ALT）水平均有所下降，與治療前比較，差異有統計學意義（P＜0.05）；且治療組治療後TBIL、TBA、ALT水平較對照組下降更明顯，差異有統計學意義（P＜0.05）。結論思美泰和優思弗聯閤用藥治療ICP較單用思美泰療效更顯著。
목적：관찰사미태（정이광산선감단안산）화우사불（웅거양담산）연합용약여사미태단용치료임신기간내담즙어적증（ICP）적료효。방법선취2010년1월지2013년1월수치적78례ICP환자，분성대조조화치료조각39례。대조조급여사미태치료，치료조급여사미태연합우사불치료，14 d위1개료정。대량조환자소양증상개선정황、잉주、간공능지표적개선진행비교。결과량조환자치료후피부소양정황명현호전，여치료전비교，차이유통계학의의（P＜0.05）；치료조치료후교대조조평분저，차이유통계학의의（P＜0.05）；치료조치료후잉주[（36.3±0.11）주]교대조조[（34.2±0.17）주]명현연장，차이유통계학의의（P＜0.05）；량조환자치료후총담홍소（TBIL）、담즙산（TBA）、병안산안기전이매（ALT）수평균유소하강，여치료전비교，차이유통계학의의（P＜0.05）；차치료조치료후TBIL、TBA、ALT수평교대조조하강경명현，차이유통계학의의（P＜0.05）。결론사미태화우사불연합용약치료ICP교단용사미태료효경현저。
Objective To observe the efficacy of Transmetil(ademetionine1,4-butanedisulfonate for injection) combined with ursodeoxycholic acid (UDCA) and Transmetil alone in the treatment of intrahepatic cholestasis of pregnancy (ICP). Meth-ods Totally 78 ICP patients,who were enrolled in the hospital from January 2010 to January 2013 ,were selected and random-ized into control group and treatment group with 39 cases in each group. The control group was given Transmetil for treatment , while the treatment group was with Transmetil combined with ursodeoxycholic acid for treatment ,14 days as a course. The im-provement of symptoms with itching,gestational weeks and improvement of liver function in both groups were compared. Results The itching in both groups improved obviously after treatment,and compared with before treatment,the difference had statisti-cally significant difference(P<0.05). The score after treatment in the treatment group was lower than that in the control group with statistically significant difference(P<0.05). The gestational weeks after treatment in the treatment group[(36.3±0.11)weeks] was pro-minently longer than that in the control group[(34.2±0.17)weeks] with statistically significant difference(P<0.05). The levels of total bilirubin (TBIL),total bile acid (TBA) and alanine aminotransferase (ALT) after treatment in both groups declined to some extent,which,compared with the control group,had statistically significant difference(P<0.05),and the levels of TBIL,TBA and ALT in the treatment groups declined more obviously than those in the control group with statistically significant difference (P<0.05). Conclusion Transmetil combined with ursodeoxycholic acid is more effective than Transmetil alone in the treatment of intrahep-atic cholestasis of pregnancy.
