CAJ | 학술논문

胃癌是我国最常见的恶性肿瘤之一，其发生发展与癌基因-抑癌基因的突变、调节失控及功能丢失有着密切关系，尤其抑癌基因p53。随着分子生物学的不断发展，p53基因突变、蛋白表达、HP感染与p53在胃癌发生发展中的作用机制不断清晰。相信随着对p53基因蛋白的深入研究，其将在胃癌早期诊断及治疗靶点中成为一新的突破点。
위암시아국최상견적악성종류지일，기발생발전여암기인-억암기인적돌변、조절실공급공능주실유착밀절관계，우기억암기인p53。수착분자생물학적불단발전，p53기인돌변、단백표체、HP감염여p53재위암발생발전중적작용궤제불단청석。상신수착대p53기인단백적심입연구，기장재위암조기진단급치료파점중성위일신적돌파점。
Gastric carcinoma is one of the most frequent malignant tumors in China, its occurrence and development have the the highest mortality rate with Cancer gene and tumor suppressor genes mutations, regulatory control and functional loss, In particular p53.With the development of molecular biology, the mechanism of action of P53 gene mutation, protein expression, HP infection and p53 in the development of gastric carcinoma is continuous clear. Along with the in-depth study of p53 gene protein, it will be a new breakthrough point in the early diagnosis of gastric carcinoma and therapeutic targets.