CAJ | 학술논문

目的：了解老年阿尔兹海默病（AD）患者肠内营养治疗前后营养状况及认知功能改善情况，探讨营养干预对改善老年AD患者认知功能障碍的作用。方法共纳入接受治疗的AD患者64例，随机分为治疗组和对照组各32例。对照组患者口服盐酸美金刚片治疗，治疗组患者在口服盐酸美金刚片基础上增加肠内营养乳剂（TPF-D）口服，观察治疗前与治疗3、6、12个月后两组患者营养和认知功能状况，分析营养干预对改善AD患者认知功能的作用。结果治疗12个月后治疗组AD患者的血红蛋白（Hbg）、清蛋白（Alb）水平及简易营养评估法（MNA）评分改善明显优于对照组，差异有统计学意义（P<0.05）；治疗6个月后，患者简易智能状态量表（MMSE）评分和日常生活能力量表（ADL）评分呈升高趋势，且治疗组ADL评分上升优于对照组（P<0.05）；治疗12个月后治疗组MMSE、ADL评分升高明显优于对照组，差异均有统计学意义（P<0.05）。结论肠内营养干预治疗AD能有效改善患者营养状况，对AD患者认知功能有一定改善作用。
목적：료해노년아이자해묵병（AD）환자장내영양치료전후영양상황급인지공능개선정황，탐토영양간예대개선노년AD환자인지공능장애적작용。방법공납입접수치료적AD환자64례，수궤분위치료조화대조조각32례。대조조환자구복염산미금강편치료，치료조환자재구복염산미금강편기출상증가장내영양유제（TPF-D）구복，관찰치료전여치료3、6、12개월후량조환자영양화인지공능상황，분석영양간예대개선AD환자인지공능적작용。결과치료12개월후치료조AD환자적혈홍단백（Hbg）、청단백（Alb）수평급간역영양평고법（MNA）평분개선명현우우대조조，차이유통계학의의（P<0.05）；치료6개월후，환자간역지능상태량표（MMSE）평분화일상생활능역량표（ADL）평분정승고추세，차치료조ADL평분상승우우대조조（P<0.05）；치료12개월후치료조MMSE、ADL평분승고명현우우대조조，차이균유통계학의의（P<0.05）。결론장내영양간예치료AD능유효개선환자영양상황，대AD환자인지공능유일정개선작용。
Objective To investigate the changes of nutritional status and cognitive function of the elderly with Alzhermer′s disease(AD) before and after eternal nutrition(EN),and explore the effect of nutritional intervention for improving the cognitive function of the elderly with AD. Methods Sixty-four patients with AD were enrolled and randomized into treatment group and control group,32 cases in each group. The control group was given memantine tablets orally,while the treatment group was added with TPF-D orally on the basis of the control group. To observe nutritional status and cognitive function before treat-ment and 3,6 and12 months after the treatment,and analyze the effect of nutrition intervention on the improvement of cognitive function in patients with AD. Results After 12 months of treatment,haemoglobin B(Hbg),Alb,MNA in AD patients of the treat-ment group was significantly better than that of the control group(P<0.05);after 6 months of treatment,the scores of MMSE and ADL appeared increasing trend,and ADL score in the treatment group increased significantly than that in the control group (P<0.05);After 12 months of treatment,the levels of MMSE and ADL in the treatment group increased significantly than those in the control group with statistically significant difference(P<0.05). Conclusions Nutrition intervention in eternal can improve the nutrition-al status of AD patients effectively,and it has certain effect in improving the cognitive function of patients with AD.