CAJ | 학술논문

目的：观察单药铂类化疗联合放疗治疗宫颈癌的疗效，比较奈达铂或顺铂化疗同步放疗对宫颈癌的近期疗效及不良反应。方法将2006年1月至2011年1月收治的48例宫颈癌患者按随机数字表法分为奈达铂组和顺铂组，每组各24例，两组均采用常规分割放疗及后装治疗，放疗总量8000~8500 Gy。奈达铂组患者从放疗第1天起给予奈达铂25 mg/m2静脉滴注，每周1次，共4～5个周期；顺铂组患者放疗第1天起给予顺铂25 mg/m2静脉滴注，每周1次，共4～5个周期。观察两组治疗效果。结果两组患者近期有效率均达100.00%，奈达铂组完全缓解20例（83.33%），顺铂组完全缓释19例（79.17%），两组比较，差异无统计学意义（P＞0.05）；在不良反应方面，奈达铂组患者食欲减退、恶心、呕吐发生情况明显低于顺铂组，差异有统计学意义（P＜0.05）；而白细胞和血小板减少例数，奈达铂组略高于顺铂组，差异无统计学意义（P＞0.05）。结论单药铂类化疗同步放疗对宫颈癌效果显著，奈达铂或顺铂化疗同步放疗对宫颈癌的疗效相似，但奈达铂致食欲减退、恶心、呕吐反应较顺铂轻，耐受性优于顺铂。
목적：관찰단약박류화료연합방료치료궁경암적료효，비교내체박혹순박화료동보방료대궁경암적근기료효급불량반응。방법장2006년1월지2011년1월수치적48례궁경암환자안수궤수자표법분위내체박조화순박조，매조각24례，량조균채용상규분할방료급후장치료，방료총량8000~8500 Gy。내체박조환자종방료제1천기급여내체박25 mg/m2정맥적주，매주1차，공4～5개주기；순박조환자방료제1천기급여순박25 mg/m2정맥적주，매주1차，공4～5개주기。관찰량조치료효과。결과량조환자근기유효솔균체100.00%，내체박조완전완해20례（83.33%），순박조완전완석19례（79.17%），량조비교，차이무통계학의의（P＞0.05）；재불량반응방면，내체박조환자식욕감퇴、악심、구토발생정황명현저우순박조，차이유통계학의의（P＜0.05）；이백세포화혈소판감소례수，내체박조략고우순박조，차이무통계학의의（P＞0.05）。결론단약박류화료동보방료대궁경암효과현저，내체박혹순박화료동보방료대궁경암적료효상사，단내체박치식욕감퇴、악심、구토반응교순박경，내수성우우순박。
Objective To observe the clinical efficacy of single-agent platinum-based chemotherapy synchronized with radiotherapy for cervical cancer ,and compare the short-term curative effects and adverse reaction between nedaplatin or cisplatin respectively synchronized with radiotherapy for cervical cancer. Methods Totally 48 patients with cervical cancer were divided into nedaplatin group and cisplatin group based on random number table ,24 cases in each group. Both groups adopted conven-tional segmentation radiation treatment and after-loading radiotherapy,to a total dose of 8 000-8 500 Gy. The nedaplatin group was with intravenous drip of nedaplatin 25 mg/m2 from the first day,once a week,totally 4-5 times;the cisplatin group was with intravenous drip of cispaltin 25 mg/m2 from the first day,once a week,totally 4-5 times. The therapeutic effect in the two groups were observed. Results The short-term effective rate in both groups reached 100.00%. Complete remission of nedaplatin group occurred in 20 cases(83.33%),which of cisplatin group occurred in 19 cases(79.17%),and there was no significant difference between the two groups on complete remission(P>0.05). In the respect of side effects,the incidence rates of loss of appetite,nausea and vomiting in nedaplatin group were significantly lower than those in the cisplatin group (P<0.05),however,the reduction rates of bone marrow inhibition of white cells and platelets in nedaplatin group were slightly higher than those in the cisplatin group without statistically significant difference(P>0.05). Conclusion The therapeutic effect of single-agent platinum-based chemother-apy synchronized with radiotherapy for cervical cancer is remarkable,in addition,two types of chemotherapy have similar curative effect in treating cervical cancer. While nedaplatin has mild side effects on loss of appetite ,nausea and vomiting compared with the cisplatin group,and its tolerance is superior to cisplatin.