CAJ | 학술논문

目的：观察冠心舒通对急性心肌梗死（AMI）基质金属蛋白酶抑制剂-1（timp-1）的影响，探讨其作用机制，为临床提供依据。方法建立大鼠的心肌梗死模型，应用冠心舒通0.4g.d-1.kg-1进行干预与心肌梗死组比较，利用逆转录- PCR技术（RT-PCR）的方法，观察心肌基质金属蛋白酶抑制剂(TIMP-1) mRNA的表达。结果急性心肌梗死后30天冠心舒通组心肌基质金属蛋白酶抑制剂(TIMP-1)mRNA表达较心肌梗死组及假手术组明显升高(P<0.01)。结论冠心舒通有助于改善急性心肌梗死预后。
목적：관찰관심서통대급성심기경사（AMI）기질금속단백매억제제-1（timp-1）적영향，탐토기작용궤제，위림상제공의거。방법건립대서적심기경사모형，응용관심서통0.4g.d-1.kg-1진행간예여심기경사조비교，이용역전록- PCR기술（RT-PCR）적방법，관찰심기기질금속단백매억제제(TIMP-1) mRNA적표체。결과급성심기경사후30천관심서통조심기기질금속단백매억제제(TIMP-1)mRNA표체교심기경사조급가수술조명현승고(P<0.01)。결론관심서통유조우개선급성심기경사예후。
Objective: To explore effects of Guanxinshutong therapy on after myocardial infarction in rats, this study measures tissue inhibitors of metal oproteinase-1 (TIMP-1) mRNA levels by RT- PCR, so as to research mechanisms of myocardial fibrosis by Guanxinshutong. Methods: The establishment of myocardial infarction model Application of Guanxinshutong 0.4g d-1. Kg-1,and myocardial infarction group , using reverse transcription - PCR technique (RT-PCR) method of myocardial inhibitors of metal oproteinase-1 increased (TIMP-1) mRNA expression. Results:Effects of Guanxinshutong to increased for 30dinhibitors of metal oproteinase-1 (TIMP-1) mRNA expression after acute myocardial infarction (P<0.01). Conclusion:Effects of Guanxinshutong help to improve the prognosis of acute myocardial infarction.