CAJ | 학술논문

目的：探讨肠道病毒感染在扩张型心肌病（ DCM ）发生发展中的作用。方法采用RT-PCR法检测109例DCM患者肠道病毒RNA表达，其中肠道柯萨奇B组病毒RNA阳性49例（阳性组），阴性60例（阴性组）。采用ELISA法测定两组血清病毒RNA表达水平，比较两组近期预后（心衰再发率、再入院率、病死率等）。结果阳性组血清肠道病毒RNA水平明显高于阴性组，P＜0．05；再入院率、急性心衰再发率、病死率均明显高于阴性组（P均＜0．05）。结论肠道病毒感染在扩张型心肌病发生发展过程中起重要作用；肠道病毒RNA高表达者近期预后较差。
목적：탐토장도병독감염재확장형심기병（ DCM ）발생발전중적작용。방법채용RT-PCR법검측109례DCM환자장도병독RNA표체，기중장도가살기B조병독RNA양성49례（양성조），음성60례（음성조）。채용ELISA법측정량조혈청병독RNA표체수평，비교량조근기예후（심쇠재발솔、재입원솔、병사솔등）。결과양성조혈청장도병독RNA수평명현고우음성조，P＜0．05；재입원솔、급성심쇠재발솔、병사솔균명현고우음성조（P균＜0．05）。결론장도병독감염재확장형심기병발생발전과정중기중요작용；장도병독RNA고표체자근기예후교차。
Objective To investigate the function of enterovirus infection in the occurrence and development of dilated cardiomyopathy (DCM).Methods Reverse transcriptase-polymerase chain reaction (RT-PCR) method was used to de-tect the enterovirus RNA expression of 109 cases of DCM patients , in which 49 patients were Coxsackie B virus RNA-posi-tive ( positive group ) and negative ones were found in 60 cases ( negative group ) .The serum coxsackievirus and adenovirus RNA contents in the two groups were detected by ELISA , and the short-term prognosis ( including mortality and readmission records and other adverse cardiac events ) was compared .Results The serum enterovirus RNA in the positive group was significantly higher than that of the negative group (P<0.05), and the readmission rate, acute heart failure recurrence rate, mortality rate were significantly higher than those of the negative group (P<0.05).Conclusion Enterovirus infec-tion plays an important role in the occurrence and development of DCM , and the short-term prognosis of patients with higher enterovirus RNA is worse .