中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
1期
22-22,23
,共2页
低级别上皮内瘤变%高级别上皮内瘤变%COX-2%VEGF
低級彆上皮內瘤變%高級彆上皮內瘤變%COX-2%VEGF
저급별상피내류변%고급별상피내류변%COX-2%VEGF
Low grade intraepithelial neoplasia%High grade intraepithelial neoplasia%Cyclooxygenase-2%Vascular endothelial growth factor
本文通过通过对胃粘膜低级别、高级别上皮内瘤变组织及胃癌组织中COX-2、VEGF表达水平的研究，探讨二者在不同程度胃粘膜病变组织中同步表达的差异性及相关的临床意义，得出结论：随着胃粘膜病变程度的加重，COX-2的表达逐渐增强，而VEGF仅在高级别上皮内瘤变组中开始呈一定水平的表达，但COX-2与VEGF的表达又成正相关，推测在胃癌的形成过程中，表达逐步增强的COX-2可能促使了VEGF的表达。
本文通過通過對胃粘膜低級彆、高級彆上皮內瘤變組織及胃癌組織中COX-2、VEGF錶達水平的研究，探討二者在不同程度胃粘膜病變組織中同步錶達的差異性及相關的臨床意義，得齣結論：隨著胃粘膜病變程度的加重，COX-2的錶達逐漸增彊，而VEGF僅在高級彆上皮內瘤變組中開始呈一定水平的錶達，但COX-2與VEGF的錶達又成正相關，推測在胃癌的形成過程中，錶達逐步增彊的COX-2可能促使瞭VEGF的錶達。
본문통과통과대위점막저급별、고급별상피내류변조직급위암조직중COX-2、VEGF표체수평적연구，탐토이자재불동정도위점막병변조직중동보표체적차이성급상관적림상의의，득출결론：수착위점막병변정도적가중，COX-2적표체축점증강，이VEGF부재고급별상피내류변조중개시정일정수평적표체，단COX-2여VEGF적표체우성정상관，추측재위암적형성과정중，표체축보증강적COX-2가능촉사료VEGF적표체。
The paper Through the research on the expression levels of COX-2 and VEGF in the gastric low grade, high grade intraepithelial neoplasia and gastric carcinoma, to explore their difference between different precancerous lesions and their clinical significance,The Conclusion: The COX-2 expression were gradual y increased as the gastric mucosal lesions aggravated, while VEGF only began to show a certain level of expression in the high-grade intraepithelial neoplasia. It is supposed that, during the formation of gastric cancer, the expression of COX-2 may promote the expression of VEGF.
