中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
13期
11-12
,共2页
左西孟旦%心力衰竭%有效性
左西孟旦%心力衰竭%有效性
좌서맹단%심력쇠갈%유효성
Levosimendan%Heart failure%Effectiveness
目的：对难治性心力衰竭患者在常规药物治疗的基础上加用左西孟旦，探讨左西孟旦的有效性和安全性。方法将难治性心力衰竭患者108例随机分为观察组52例和对照组56例，对照组患者予以常规药物治疗(如利尿剂、地高辛等)，观察组患者予以常规治疗的同时加用左西孟旦静脉注射，两组均予以抗感染、限盐、限水、纠正诱发因素等基础治疗。观察两组患者的临床症状改善情况、左室射血分数以及不良反应的发生率。结果观察组患者的有效率（40.4%；25.0%）及总有效率（86.6%；60.7%）均显著高于对照组（P<0.05），无效率（13.4%；39.3%）显著低于对照组（P<0.05）；观察组与对照组治疗后与治疗前相比，左室射血分数均有提高，但观察组提高的幅度明显高于对照组（P<0.05）。结论左西孟旦可有效提高难治性心力衰竭患者的射血分数，具有较好的有效性和安全性。
目的：對難治性心力衰竭患者在常規藥物治療的基礎上加用左西孟旦，探討左西孟旦的有效性和安全性。方法將難治性心力衰竭患者108例隨機分為觀察組52例和對照組56例，對照組患者予以常規藥物治療(如利尿劑、地高辛等)，觀察組患者予以常規治療的同時加用左西孟旦靜脈註射，兩組均予以抗感染、限鹽、限水、糾正誘髮因素等基礎治療。觀察兩組患者的臨床癥狀改善情況、左室射血分數以及不良反應的髮生率。結果觀察組患者的有效率（40.4%；25.0%）及總有效率（86.6%；60.7%）均顯著高于對照組（P<0.05），無效率（13.4%；39.3%）顯著低于對照組（P<0.05）；觀察組與對照組治療後與治療前相比，左室射血分數均有提高，但觀察組提高的幅度明顯高于對照組（P<0.05）。結論左西孟旦可有效提高難治性心力衰竭患者的射血分數，具有較好的有效性和安全性。
목적：대난치성심력쇠갈환자재상규약물치료적기출상가용좌서맹단，탐토좌서맹단적유효성화안전성。방법장난치성심력쇠갈환자108례수궤분위관찰조52례화대조조56례，대조조환자여이상규약물치료(여이뇨제、지고신등)，관찰조환자여이상규치료적동시가용좌서맹단정맥주사，량조균여이항감염、한염、한수、규정유발인소등기출치료。관찰량조환자적림상증상개선정황、좌실사혈분수이급불량반응적발생솔。결과관찰조환자적유효솔（40.4%；25.0%）급총유효솔（86.6%；60.7%）균현저고우대조조（P<0.05），무효솔（13.4%；39.3%）현저저우대조조（P<0.05）；관찰조여대조조치료후여치료전상비，좌실사혈분수균유제고，단관찰조제고적폭도명현고우대조조（P<0.05）。결론좌서맹단가유효제고난치성심력쇠갈환자적사혈분수，구유교호적유효성화안전성。
Objective To observe the efficacy and safety of levosimendan on the basis of routine drug treatment for patients with refractory heart failure. Methods 108 cases of refractory heart failure patients were randomly divided into the observation group (n=52) and the control group (n=56). Patients in the control group were given routine drug treatment, such as diuretic, digoxin and so on, the observation group patients were given intravenous injection of levosimendan on the basis of the conventional treatment. And both groups were also given the basic treatment such as anti-infection, limitation of salt and water, correcting the inducing factors and so forth. The improvement of clinical symptoms, left ventricular ejection fraction and the incidence of adverse reactions of two groups were observed. Results The effective rate (40.4%; 25.0%) and the total effective rate (86.6%, 60.7%) of observation group were significantly higher than those of control group (P<0.05); ineffective rate (13.4%; 39.3%) of observation group was sig-nificantly lower than that of control group (P<0.05). The left ventricular ejection fraction of both groups increased after treatment compared with that before treatment, but the increase rate of the observation group was significantly higher than that of the control group(P<0.05). Conclusion Levosimendan can effectively improve the ejection fraction in patients with refractory heart failure, and has better efficacy and safety.
