CAJ | 학술논문

目的：探讨血浆氨基末端脑钠肽前体（NT-proBNP）与冠心病（CHD）患者冠状动脉病变程度的相关性。方法选择2011~2013年临床拟诊为CHD患者120例，按冠状动脉CT血管造影（CTA）结果分为阳性组（70例）和阴性组（50例），阳性组按冠状动脉病变程度分为单支病变组（24例）、双支病变组（25例）和多支病变组（21例）。结果冠状动脉CTA阴性组患者血浆NT-proBNP水平为（389.4±115.9）pg/mL；冠状动脉CTA 阳性组患者血浆NT-proBNP 水平为（881.6±670.6）pg/mL，二者比较，差异有统计学意义（t=10.5，P＜0.01）。冠状动脉CTA阳性组随着冠状动脉病变的严重程度增加，其各组血浆NT-proBNP水平逐渐增高。冠状动脉CTA阳性组各亚组即单支病变组与双支病变组之间、双支病变与多支病变组之间、单支病变与多支病变组NT-proBNP水平比较，差异均有统计学意义（t=8.9、7.5、8.5，P＜0.05或0.01）。结论 CHD患者血浆NT-proBNP水平与疾病的严重程度有一定相关性，且随着冠状动脉病变程度的增加，其血浆NT-proBNP水平逐渐增加。
목적：탐토혈장안기말단뇌납태전체（NT-proBNP）여관심병（CHD）환자관상동맥병변정도적상관성。방법선택2011~2013년림상의진위CHD환자120례，안관상동맥CT혈관조영（CTA）결과분위양성조（70례）화음성조（50례），양성조안관상동맥병변정도분위단지병변조（24례）、쌍지병변조（25례）화다지병변조（21례）。결과관상동맥CTA음성조환자혈장NT-proBNP수평위（389.4±115.9）pg/mL；관상동맥CTA 양성조환자혈장NT-proBNP 수평위（881.6±670.6）pg/mL，이자비교，차이유통계학의의（t=10.5，P＜0.01）。관상동맥CTA양성조수착관상동맥병변적엄중정도증가，기각조혈장NT-proBNP수평축점증고。관상동맥CTA양성조각아조즉단지병변조여쌍지병변조지간、쌍지병변여다지병변조지간、단지병변여다지병변조NT-proBNP수평비교，차이균유통계학의의（t=8.9、7.5、8.5，P＜0.05혹0.01）。결론 CHD환자혈장NT-proBNP수평여질병적엄중정도유일정상관성，차수착관상동맥병변정도적증가，기혈장NT-proBNP수평축점증가。
Objective To investigate the relationship between plasma n-terminal pro-brain natriuretic (NT-proBNP) peptide and severity of coronary artery lesions in patients with coronary heart diseases (CHD). Methods A total of 120 patients with suspected CHD in clinic were divided into positive group(n=70) and negative group(n=50) according to the results of coro-nary computed tomography angioplasty(CTA). The positive group was divided into three sub-groups:single vessel disease group (n=24),double vessel disease group(n=25) and multiple vessel group(n=21). Results The level of plasma NT-proBNP was (389.4±115.9)pg/mL in negative group and (881.6±670.6)pg/mL in positive group,and the difference between the two groups had statistical significance (t=10.5,P<0.01). With the increase of severity,the level of NT-proBNP in three sub-groups increased. The comparison of NT-proBNP level in the three sub-groups (single vessel group,double vessel group and multiple vessel group) of positive group had statistically significant difference(t=8.9,7.5,8.5;P<0.05 or 0.01). Conclusion The plasma concentration of NT-proBNP in patients with CHD has certain relevance with the severity of the disease ,and the plasma NT-proBNP level increases with the degree of the coronary artery lesions.