CAJ | 학술논문

原发免疫性血小板减少症（Primary immune thrombocytopenic purpura ITP）是一种常见的以皮肤黏膜、内脏出血为主要临床表现的自身免疫性疾病，其发病机制尚未完全明确。目前认为体液和细胞免疫介导的血小板过度破坏、巨核细胞数量和质量异常、血小板生成不足是该病的主要发病机制。近年来，随着对ITP发病机制的不断深入研究，补体作用、滤泡辅助性T细胞的异常等许多观点引起了越来越多的关注，本文将对ITP的发病机制的研究进展做一综述。
원발면역성혈소판감소증（Primary immune thrombocytopenic purpura ITP）시일충상견적이피부점막、내장출혈위주요림상표현적자신면역성질병，기발병궤제상미완전명학。목전인위체액화세포면역개도적혈소판과도파배、거핵세포수량화질량이상、혈소판생성불족시해병적주요발병궤제。근년래，수착대ITP발병궤제적불단심입연구，보체작용、려포보조성T세포적이상등허다관점인기료월래월다적관주，본문장대ITP적발병궤제적연구진전주일종술。
Primary immune thrombocytopenia (ITP), is the most common clinical autoimmune disorder and the pathogenesis is not completely clear, which clinical features are mucocutaneous bleeding and visceral hemorrhage.The main Pathogenesis of ITP includes humoral and cellular immunity-mediated platelet destruction,abnormal magakaryoyte quantity and quality, suppressed platelet production.In recenct years, The opinions of complement system and T fol icular helper cells has caused more attention, This review wil be made to sum up the study progress on the pathogenesisof ITP.