中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
12期
82-82
,共1页
结直肠癌%miR-21%临床意义
結直腸癌%miR-21%臨床意義
결직장암%miR-21%림상의의
Colorectal%cancer miR-21%Clinical significance
目的：分析结直肠癌组织中m i R-21的表达及其临床病理学意义。方法：选取我院2012年1月-2012年12月间手术切除的结直肠癌标本30例作为研究对象，通过采用TaqMan实时定量RT-PCR法对该组标本中的结直肠癌组织miR-21的表达进行检测，并与其癌旁正常组织miR-21的表达进行对比观察，从而探讨结直肠癌临床病理因素与miR-21的表达之间的关系。结果：通过与对比癌旁正常组织miR-21的表达进行对比观察发现，结直肠癌组织miR-21的表达明显要高很多，差异具有统计学意义（P<0．05）。结直肠癌组织miR-21的表达与患者的年龄、性别、肿瘤部位等情况没有较大的关联，而与其淋巴结转移、肿瘤病理学分级、及术后生存率三个方面有着紧密的关系。结论：结直肠癌组织miR-21的表达要高于正常组织，并且它可能与大肠癌的发生及肿瘤的生长有着密切的联系。
目的：分析結直腸癌組織中m i R-21的錶達及其臨床病理學意義。方法：選取我院2012年1月-2012年12月間手術切除的結直腸癌標本30例作為研究對象，通過採用TaqMan實時定量RT-PCR法對該組標本中的結直腸癌組織miR-21的錶達進行檢測，併與其癌徬正常組織miR-21的錶達進行對比觀察，從而探討結直腸癌臨床病理因素與miR-21的錶達之間的關繫。結果：通過與對比癌徬正常組織miR-21的錶達進行對比觀察髮現，結直腸癌組織miR-21的錶達明顯要高很多，差異具有統計學意義（P<0．05）。結直腸癌組織miR-21的錶達與患者的年齡、性彆、腫瘤部位等情況沒有較大的關聯，而與其淋巴結轉移、腫瘤病理學分級、及術後生存率三箇方麵有著緊密的關繫。結論：結直腸癌組織miR-21的錶達要高于正常組織，併且它可能與大腸癌的髮生及腫瘤的生長有著密切的聯繫。
목적：분석결직장암조직중m i R-21적표체급기림상병이학의의。방법：선취아원2012년1월-2012년12월간수술절제적결직장암표본30례작위연구대상，통과채용TaqMan실시정량RT-PCR법대해조표본중적결직장암조직miR-21적표체진행검측，병여기암방정상조직miR-21적표체진행대비관찰，종이탐토결직장암림상병리인소여miR-21적표체지간적관계。결과：통과여대비암방정상조직miR-21적표체진행대비관찰발현，결직장암조직miR-21적표체명현요고흔다，차이구유통계학의의（P<0．05）。결직장암조직miR-21적표체여환자적년령、성별、종류부위등정황몰유교대적관련，이여기림파결전이、종류병이학분급、급술후생존솔삼개방면유착긴밀적관계。결론：결직장암조직miR-21적표체요고우정상조직，병차타가능여대장암적발생급종류적생장유착밀절적련계。
objective: to analysis of miR - 21 expression in colorectal cancer tissues and its clinical pathological significance. Methods: from January 2012 to December 2012 surgical resection of colorectal cancer specimens from 30 cases as the research object, by adopting the TaqMan real-time quantitative rt-pcr method to this group of specimens of colorectal cancer tissue miR - 21 expression, and normal tissue adjacent to carcinoma with miR - comparing the expression of 21 observation, which discuss clinicopathological factors of colorectal cancer with the relationship between the expression of miR - 21. Results: by contrast with the normal tissue adjacent to carcinoma miR - comparing the expression of 21 observation found that miR - 21 expression of colorectal cancer tissues has much higher, the difference is statisticaly significant (P < 0.05). The expression of colorectal cancer tissue miR - 21 with the patient's age, gender, tumor location, and so on and so forth no larger correlation, and lymph node metastasis, tumor pathology classification, and postoperative survival rate three aspects have close relation. Conclusion: the expression of colorectal cancer tissue miR - 21 than in normal tissue, and it may be related to the occurrence of colorectal cancer and tumor growth is closely related.
