山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
21期
13-15
,共3页
李玲琴%青玉凤%周畅%周京国
李玲琴%青玉鳳%週暢%週京國
리령금%청옥봉%주창%주경국
痛风,原发性%临床特点%危险因素%Logistic回归分析
痛風,原髮性%臨床特點%危險因素%Logistic迴歸分析
통풍,원발성%림상특점%위험인소%Logistic회귀분석
gout,primary%clinical characteristics%risk factors%logistic regression analysis
目的：探讨川东北地区原发性痛风的临床特点及发病危险因素。方法采用统一调查表，对583例原发性痛风患者及459例健康体检者进行临床调查及相关实验室指标检测，采用Logistic回归分析痛风的发病危险因素。结果①94．9％的患者首次发作时累及一个关节，其中累及第一跖趾关节者占68．6％。②痛风发作无诱因者占37．6％；有诱因者占62．4％，其中88．2％与饮食因素有关。③痛风并发痛风石者占12．2％，高血压者占35．7％，高脂血症者占66．9％。④并发痛风石者多发生于痛风后3～8年，其病程长于无痛风石患者，血尿酸（sUA）水平高于无痛风石患者（P均＜0．01）。⑤Logistic回归分析发现，高sUA、饮酒、BMI、高TG、高嘌呤饮食、高血压及吸烟均与痛风发病相关（P＜0．01或＜0．05）。结论原发性痛风发病受多因素影响，高sUA、饮酒、BMI、高TG、高嘌呤饮食、高血压及吸烟均可能增加其发病风险。
目的：探討川東北地區原髮性痛風的臨床特點及髮病危險因素。方法採用統一調查錶，對583例原髮性痛風患者及459例健康體檢者進行臨床調查及相關實驗室指標檢測，採用Logistic迴歸分析痛風的髮病危險因素。結果①94．9％的患者首次髮作時纍及一箇關節，其中纍及第一蹠趾關節者佔68．6％。②痛風髮作無誘因者佔37．6％；有誘因者佔62．4％，其中88．2％與飲食因素有關。③痛風併髮痛風石者佔12．2％，高血壓者佔35．7％，高脂血癥者佔66．9％。④併髮痛風石者多髮生于痛風後3～8年，其病程長于無痛風石患者，血尿痠（sUA）水平高于無痛風石患者（P均＜0．01）。⑤Logistic迴歸分析髮現，高sUA、飲酒、BMI、高TG、高嘌呤飲食、高血壓及吸煙均與痛風髮病相關（P＜0．01或＜0．05）。結論原髮性痛風髮病受多因素影響，高sUA、飲酒、BMI、高TG、高嘌呤飲食、高血壓及吸煙均可能增加其髮病風險。
목적：탐토천동북지구원발성통풍적림상특점급발병위험인소。방법채용통일조사표，대583례원발성통풍환자급459례건강체검자진행림상조사급상관실험실지표검측，채용Logistic회귀분석통풍적발병위험인소。결과①94．9％적환자수차발작시루급일개관절，기중루급제일척지관절자점68．6％。②통풍발작무유인자점37．6％；유유인자점62．4％，기중88．2％여음식인소유관。③통풍병발통풍석자점12．2％，고혈압자점35．7％，고지혈증자점66．9％。④병발통풍석자다발생우통풍후3～8년，기병정장우무통풍석환자，혈뇨산（sUA）수평고우무통풍석환자（P균＜0．01）。⑤Logistic회귀분석발현，고sUA、음주、BMI、고TG、고표령음식、고혈압급흡연균여통풍발병상관（P＜0．01혹＜0．05）。결론원발성통풍발병수다인소영향，고sUA、음주、BMI、고TG、고표령음식、고혈압급흡연균가능증가기발병풍험。
Objective To explore the clinical features and related risk factors of primary gout in the northeastern area of China .Methods A clinical investigation and related laboratory indicator detections of primary gout were made on 583 cases of patients with primary gout and 459 healthy persons by a unified questionnaire .Then, logistic regression analysis was applied in analyzing related risk factors .Results (1) Only a joint was involved in the first attack of 94.9% of pa-tients, while the first metatarsophalangeal joint accounted for 68.6%.(2) 37.6%of patients didn't have predisposing fac-tors, 62.4%of patients had predisposing factors , during which 88.2%of 364 patients was related with beer, sea food and other dietary factors.(3) The rates of patients complicated with tophus , hypertension and hyperlipidemia were 12.2%, 35.7%and 66.9%.(4) Tophus occurred in the 3-8 years after the gout, when we compared with patients without tophus , the course of disease was longer , and the level of serum uric acid ( SUA) was significantly higher than that of patients with tophus (all P<0.01).(5) Logistic regression analysis indicated the occurrence of primary gout was related to the follow-ing factors:hyperuricemia, drinking, BMI, hypertriglyceridemia, eating habits, hypertension and smoking (P<0.01 or P<0.05).Conclusion Primary gout is affected by many factors; hyperuricemia, drinking, BMI, high TG, high purine diet, hypertension and smoking may increase the onset risk .
