中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
15期
61-62
,共2页
王海梅%邵卿%梅胜尧%乔红群%刘晶
王海梅%邵卿%梅勝堯%喬紅群%劉晶
왕해매%소경%매성요%교홍군%류정
硝酸芬替康唑%阴道刺激性%安全性
硝痠芬替康唑%陰道刺激性%安全性
초산분체강서%음도자격성%안전성
Fenticonazole Nitrate%Vaginal irritation%Safety
目的:探讨硝酸芬替康唑凝胶按规定剂量给予兔阴道后对阴道的刺激性,为临床研究用药提供参考。方法选取新西兰兔8只,雌性,按体重随机分为两组,给药1次/d,连续7 d,末次给药后24 h处死动物,取阴道进行病理组织学检查。结果空白凝胶组4只动物阴道粘膜上皮细胞无明显变性、坏死,固有膜血管未见明显扩张充血,血管周围未见明显炎细胞浸润;硝酸芬替康唑组4只动物阴道黏膜固有层均见成纤维细胞增生,部分黏膜上皮脱落,并且1号阴道黏膜固有层见较多的坏死的中性粒细胞。结论连续给予硝酸芬替康唑阴道凝胶对阴道局部有一定的刺激性,有可能会引起部分阴道黏膜上皮脱落及局部水肿等炎症改变。
目的:探討硝痠芬替康唑凝膠按規定劑量給予兔陰道後對陰道的刺激性,為臨床研究用藥提供參攷。方法選取新西蘭兔8隻,雌性,按體重隨機分為兩組,給藥1次/d,連續7 d,末次給藥後24 h處死動物,取陰道進行病理組織學檢查。結果空白凝膠組4隻動物陰道粘膜上皮細胞無明顯變性、壞死,固有膜血管未見明顯擴張充血,血管週圍未見明顯炎細胞浸潤;硝痠芬替康唑組4隻動物陰道黏膜固有層均見成纖維細胞增生,部分黏膜上皮脫落,併且1號陰道黏膜固有層見較多的壞死的中性粒細胞。結論連續給予硝痠芬替康唑陰道凝膠對陰道跼部有一定的刺激性,有可能會引起部分陰道黏膜上皮脫落及跼部水腫等炎癥改變。
목적:탐토초산분체강서응효안규정제량급여토음도후대음도적자격성,위림상연구용약제공삼고。방법선취신서란토8지,자성,안체중수궤분위량조,급약1차/d,련속7 d,말차급약후24 h처사동물,취음도진행병리조직학검사。결과공백응효조4지동물음도점막상피세포무명현변성、배사,고유막혈관미견명현확장충혈,혈관주위미견명현염세포침윤;초산분체강서조4지동물음도점막고유층균견성섬유세포증생,부분점막상피탈락,병차1호음도점막고유층견교다적배사적중성립세포。결론련속급여초산분체강서음도응효대음도국부유일정적자격성,유가능회인기부분음도점막상피탈락급국부수종등염증개변。
Objective To observe the vaginal irritation of Fenticonazole Nitrate Gel given to rabbit vaginal according to the pre-scribed dose, so as to provide a reference for the study of clinical medication. Methods 8 New Zealand female rabbits were ran-domly divided into two groups according to the weight. Fenticonazole Nitrate Gel was administrated to them q.d. for 7 d. The rab-bits were killed 24h after the last administration, and the vagina was taken for histopathological examination. Results In the 4 rab-bits of the blank gel contrast group, no obvious degeneration and necrosis was found in vaginal epithelial cells, no palpable dilata-tion and congestion was found in intrinsic membrane vascular and no obvious inflammatory cells infiltration was found around the vessels; but in the Fenticonazole Nitrate Gel group, fibroblast proliferation and some epithelial exfoliation were found in vaginal mucosa lamina propria of 4 rabbits, and many necrosis neutrophils were found in vaginal mucosa lamina propria of No. 1 rabbit. Conclusion Continuous administration of Fenticonazole Nitrate Gel has certain irritation on local vaginal, it may cause partial vaginal epithelial exfoliation, local edema and other inflammatory changes.