中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
16期
7-8
,共2页
重楼%H22%抗肿瘤
重樓%H22%抗腫瘤
중루%H22%항종류
total flavonoids from Paris%Polyphyl a Smith%H22 antitumor
目的：探讨重楼总皂苷对小鼠H22移植瘤的生长抑制作用。方法将建立的H22荷瘤小鼠模型分为模型组，重楼总皂苷高、低剂量组和环磷酰胺组，总皂苷组连续给药10d，环磷酰胺组隔日给药。结果与模型组相比，重楼总皂苷能显著抑制肿瘤生长，脾脏指数和胸腺指数与模型组比较升高，血清T N F-α和IL-2的水平提高，血清T-AOC水平提高和血清MDA的水平降低。结论重楼总皂苷对H22移植瘤具有明显的抑制作用，其作用机制可能与提高小鼠免疫功能和增强抗氧化能力有关。
目的：探討重樓總皂苷對小鼠H22移植瘤的生長抑製作用。方法將建立的H22荷瘤小鼠模型分為模型組，重樓總皂苷高、低劑量組和環燐酰胺組，總皂苷組連續給藥10d，環燐酰胺組隔日給藥。結果與模型組相比，重樓總皂苷能顯著抑製腫瘤生長，脾髒指數和胸腺指數與模型組比較升高，血清T N F-α和IL-2的水平提高，血清T-AOC水平提高和血清MDA的水平降低。結論重樓總皂苷對H22移植瘤具有明顯的抑製作用，其作用機製可能與提高小鼠免疫功能和增彊抗氧化能力有關。
목적：탐토중루총조감대소서H22이식류적생장억제작용。방법장건립적H22하류소서모형분위모형조，중루총조감고、저제량조화배린선알조，총조감조련속급약10d，배린선알조격일급약。결과여모형조상비，중루총조감능현저억제종류생장，비장지수화흉선지수여모형조비교승고，혈청T N F-α화IL-2적수평제고，혈청T-AOC수평제고화혈청MDA적수평강저。결론중루총조감대H22이식류구유명현적억제작용，기작용궤제가능여제고소서면역공능화증강항양화능력유관。
Objectives The objective of this paper was to investigate the effects of extracting total flavonoids from Paris Polyphyl a Smith on the antitumor action in a sample of H22 tumor bearing mice.Methods The H22 tumor bearing mice were divided into 4 groups: control group, high dose and low dose of Paris Polyphyl a Smith, and the Endoxan group. The 2 Groups were continuously adminatrated Paris Polyphyl a Smith on a daily basis for ten days, the Endoxan group was adminatrated drug every other day.Results Compare to the control group, the extracting total flavonoids from Paris Polyphyl a Smith has been proved to have great effects on anti tumor. serum TNF-a and IL-2 level have been improved, while serum T-AOC and MDA level have been decreased.Conclusions The extracting total flavonoids from Paris Polyphyl a Smith has signifant effects on control ing the development of H22 tumor, probably the antitumor effects were as a result of enhancing the system immune function and antioxidant effects.
