CAJ | 학술논문

目的：研究急性缺血性卒中患者血清可溶性 P-选择素（ sP-selectin）、高敏 C反应蛋白（ hs-CRP）水平与颈动脉粥样硬化程度的关系。方法选择发病72 h 内急性脑梗死患者120例，采用ELISA法测定患者血清sP-selectin及hs-CRP浓度，并应用颈动脉超声对斑块特点进行分析。结果不同颈总动脉内-中膜厚度、不同颈动脉斑块性质、不同颈动脉狭窄程度时，sP-selectin水平存在显著性差异（ P＜0.05）；随着颈总动脉内-中膜厚度越厚，颈动脉斑块稳定性越差，颈动脉狭窄程度越重，sP -selectin 水平越高，而 hs -CRP 差异不显著。结论急性缺血性卒中患者sP-selectin水平随着颅外段颈动脉粥样硬化程度加重而升高，sP-selectin与动脉粥样硬化呈正相关；且较 hs-CRP更好地反映了颈动脉粥样硬化的程度。
목적：연구급성결혈성졸중환자혈청가용성 P-선택소（ sP-selectin）、고민 C반응단백（ hs-CRP）수평여경동맥죽양경화정도적관계。방법선택발병72 h 내급성뇌경사환자120례，채용ELISA법측정환자혈청sP-selectin급hs-CRP농도，병응용경동맥초성대반괴특점진행분석。결과불동경총동맥내-중막후도、불동경동맥반괴성질、불동경동맥협착정도시，sP-selectin수평존재현저성차이（ P＜0.05）；수착경총동맥내-중막후도월후，경동맥반괴은정성월차，경동맥협착정도월중，sP -selectin 수평월고，이 hs -CRP 차이불현저。결론급성결혈성졸중환자sP-selectin수평수착로외단경동맥죽양경화정도가중이승고，sP-selectin여동맥죽양경화정정상관；차교 hs-CRP경호지반영료경동맥죽양경화적정도。
Objective It is tO investigate the assOciatiOn between levels Of serum sP -selectin,hs -CRP and extracranial carOtid arteriOsclerOsis in patients with acute ischemic strOke. Methods 120 inpatients with acute ischemic strOke attacking within 72 hOurs were selected and the serum sP-selectin,hs-CRP were measured by ELISA. A cOlOr DOppler ultrasOund sys-tem was used tO detect the plaque Of carOtid artery. Results The serum cOncentratiOns Of sP-selectin were different when the intima-media thickness Of ECCA,the nature Of plaque and the level Of carOtid artery stenOsis were different(P <0. 05). The thicker the intima-media Of ECCA was,the higher the instability Of plaque and the severer the carOtid artery stenOsis were,the higher the serum sP-selectin was,while hhs-CRP had nO statistical difference(P >0. 05). Conclusion The severer ex-tracranial carOtid atherOsclerOsis is the higher the serum cOncentratiOns Of sP -selectin are in acute ischemic strOke patients. There is a pOsitive relatiOnship between serum sP-selectin and carOtid atherOsclerOsis,and the activity is mOre sensitive than Hs-CRP in the detectiOn Of carOtid atherOsclerOsis.