CAJ | 학술논문

目的：评价伊班膦酸钠和帕米膦酸二钠治疗骨转移癌疼痛的临床疗效和安全性。方法62例患者随机分为伊班膦酸钠组和帕米膦酸二钠组各31例，伊斑膦酸钠组给予伊班膦酸钠治疗，帕米膦酸二钠组给予帕米膦酸二钠治疗，2组均用药2～6个周期。观察2组用药后止痛效果、骨修复、活动能力及不良反应发生情况。结果用药第14天时伊班膦酸钠组临床获益率为87.1％高于帕米膦酸二钠组的64.5％，差异有统计学意义(P<0.05)；治疗56d伊班膦酸钠组临床获益率为90.3％，帕米膦酸二钠组为83.8％，差异无统计学意义( P>0.05)。2组主要不良反应主要为发热、乏力，严重程度与骨质损害呈相关。结论伊班膦酸钠治疗骨转移癌疼痛疗效略优于帕米膦酸二钠，两者不良反应均较轻，均有良好的耐受性，值得临床推广应用。
목적：평개이반련산납화파미련산이납치료골전이암동통적림상료효화안전성。방법62례환자수궤분위이반련산납조화파미련산이납조각31례，이반련산납조급여이반련산납치료，파미련산이납조급여파미련산이납치료，2조균용약2～6개주기。관찰2조용약후지통효과、골수복、활동능력급불량반응발생정황。결과용약제14천시이반련산납조림상획익솔위87.1％고우파미련산이납조적64.5％，차이유통계학의의(P<0.05)；치료56d이반련산납조림상획익솔위90.3％，파미련산이납조위83.8％，차이무통계학의의( P>0.05)。2조주요불량반응주요위발열、핍력，엄중정도여골질손해정상관。결론이반련산납치료골전이암동통료효략우우파미련산이납，량자불량반응균교경，균유량호적내수성，치득림상추엄응용。
0bjective To evaluate the clinical therapeutic effect and safeness of ibandronate and pamidronate in treating pain caused by bone metastasis.Methods 62 cases were randomly divided into ibandronate group and pamidronate group,31 cases of each.The ibandronate group was treated with ibandronate,while the pamidronate group was treated with. Both groups were treated for 2 to 6 cylces.Observed 2 group’s odynolysis effect,situations of bone reparation,activity ability and adverse reaction.Results On the 14th day of administration,the clinical benefit rate of ibandronate group was 87.1% higher than 64.5% of the pamidronate group,and the difference was statistical y significant(P<0.05). On the 56th day of administration.the clinical benefit rate of ibandronate group was 90.3% higher than 83.8% of the pamidronate group,and the difference was of no statistical significance(P>0.05).The main adverse reactions of 2 groups were fewer and weakness,and the severity had positive correlation with bone damage.Conclusion Ibandronate has good curative effects above pamidronate in treating pain caused by bone metastasis.Both of the two drugs has slight adverse reaction and good tolerance.Which are worth clinical popularizing and application.