中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
9期
9-10
,共2页
乙型肝炎%中医治疗%免疫调节%T细胞免疫功能
乙型肝炎%中醫治療%免疫調節%T細胞免疫功能
을형간염%중의치료%면역조절%T세포면역공능
Traditional%Chinese Medicine Immunity Reforming%Hepatitis b%Nucleoside analogues.%T cel immune function
目的：用中药护肝I号联合恩替卡韦，治疗慢性病毒乙肝的疗效探讨；方法：选择初治慢性乙肝患者400例，随机分成治疗组和对照组各200例，治疗组采用中药护肝I号，恩替卡韦分散片；对照组单纯采用恩替卡韦分散片；观察两组病人治疗后的生化、病毒、以及T细胞指数的变化；结果：治疗组显效率明显高于对照组.两组治疗后肝功能、HBV-DNA水平均明显下降, HBeAg/HBeAb转换率高，CD4+水平明显升高（P<0.05），CD8+明显下降（P<0.05）；两组患者服药24个月停药,3个月后检查,肝功能、H B V-D N A，治疗组反弹率为5.50%，对照组反弹率为44.00%，两组存在显著差别（P<0.01）；结论：中药护肝I号治疗慢性乙型肝炎可以提高恩替卡韦抗乙肝病毒的疗效，降低反弹率。
目的：用中藥護肝I號聯閤恩替卡韋，治療慢性病毒乙肝的療效探討；方法：選擇初治慢性乙肝患者400例，隨機分成治療組和對照組各200例，治療組採用中藥護肝I號，恩替卡韋分散片；對照組單純採用恩替卡韋分散片；觀察兩組病人治療後的生化、病毒、以及T細胞指數的變化；結果：治療組顯效率明顯高于對照組.兩組治療後肝功能、HBV-DNA水平均明顯下降, HBeAg/HBeAb轉換率高，CD4+水平明顯升高（P<0.05），CD8+明顯下降（P<0.05）；兩組患者服藥24箇月停藥,3箇月後檢查,肝功能、H B V-D N A，治療組反彈率為5.50%，對照組反彈率為44.00%，兩組存在顯著差彆（P<0.01）；結論：中藥護肝I號治療慢性乙型肝炎可以提高恩替卡韋抗乙肝病毒的療效，降低反彈率。
목적：용중약호간I호연합은체잡위，치료만성병독을간적료효탐토；방법：선택초치만성을간환자400례，수궤분성치료조화대조조각200례，치료조채용중약호간I호，은체잡위분산편；대조조단순채용은체잡위분산편；관찰량조병인치료후적생화、병독、이급T세포지수적변화；결과：치료조현효솔명현고우대조조.량조치료후간공능、HBV-DNA수평균명현하강, HBeAg/HBeAb전환솔고，CD4+수평명현승고（P<0.05），CD8+명현하강（P<0.05）；량조환자복약24개월정약,3개월후검사,간공능、H B V-D N A，치료조반탄솔위5.50%，대조조반탄솔위44.00%，량조존재현저차별（P<0.01）；결론：중약호간I호치료만성을형간염가이제고은체잡위항을간병독적료효，강저반탄솔。
Purpose. By using traditional Chinese medicine dialectical method, reforming Immunity to enhance therapeutic efficacy that nucleoside analogs inhibit HBV, as wel as explore it’s immunity mechanism.Method.:Selecting 400 cases patients with chronic hepatitis b (CHB) and divide them into two groups, treatment group and control group. Treatment group, using traditional Chinese medicine modified decoction for invigorating the spleen and kidney, and routine Entecavir Dispersible Tablets. Control group, only using Entecavir Dispersible Tablets. Observing their clinical efficacy and cel cular immunity changes after treating.Result. Significantly effective rate of Traditional Chinese Medicine Immunity Reforming Method is obviously higher than control group (P<0.01). After treatment of two groups, their standards of liver function, HBV-DNA are both decreased significantly(P<0.01,P<0.05). The treatment group’s turnover rate is high after treating, standard of CD4+ is obviously increased (P<0.05), and CD8+ is obviously decreased(P<0.05). The control group’s standards of CD4+and CD8+ is both without significant changes (P>0.05). Drug withdrawal when two group’s patients taking medicine for 24 months, and test their liver function and HBV-DNA, the bounce rate of treatment group is 5.50%, and 44.00% of control group. There are significant differences between them (P<0.01). Conclusion. Traditional Chinese Medicine Reforming Method could improve the efficacy that nucleoside analogs inhibit HBV and lower bounce rate.
