中外健康文摘
中外健康文摘
중외건강문적
WORLD HEALTH DIGEST
2014年
9期
140-140,141
,共2页
胃蛋白酶原Ⅰ%胃蛋白酶原Ⅱ%胃溃疡
胃蛋白酶原Ⅰ%胃蛋白酶原Ⅱ%胃潰瘍
위단백매원Ⅰ%위단백매원Ⅱ%위궤양
pepsinogenⅠ%epsinogenⅡ%gastric ulcer
目的：：探讨胃蛋白酶原Ⅰ（P GⅠ）和胃蛋白酶原Ⅱ（P GⅡ）检测对胃溃疡患者的筛查作用。方法：选取2013年1月-10月在青浦中心医院的体检者2052例，胃溃疡患者120例，分别检测血清P GⅠ和P GⅡ，并计算P GⅠ/P GⅡ比值，统计学分析三个指标在体检者与胃溃疡患者之间的差异。结果：胃溃疡患者血清PGⅠ、PGⅡ和PGⅠ/PGⅡ分别为316.7±129.2ng/ml、40.2±30.1ng/ml 和12.0±4.9，三者均显著高于体检人群（156.0±63.8ng/ml，15.9±11.1ng/ml 和9.7±4.3）（P<0.05）。如果以体检人群95%的可信区间设定正常参考值，则PGⅠ、PGⅡ和PGⅠ/PGⅡ的参考值分别为<270.9ng/ml、<37.8n g/m l和<14.4，它们对胃溃疡的阳性预期值分别为61.7%、55.8%和13.3%。结论：胃溃疡患者血清P GⅠ和P GⅡ水平均显著高于体检者，因此它们可能用于大规模人群胃溃疡的筛查。
目的：：探討胃蛋白酶原Ⅰ（P GⅠ）和胃蛋白酶原Ⅱ（P GⅡ）檢測對胃潰瘍患者的篩查作用。方法：選取2013年1月-10月在青浦中心醫院的體檢者2052例，胃潰瘍患者120例，分彆檢測血清P GⅠ和P GⅡ，併計算P GⅠ/P GⅡ比值，統計學分析三箇指標在體檢者與胃潰瘍患者之間的差異。結果：胃潰瘍患者血清PGⅠ、PGⅡ和PGⅠ/PGⅡ分彆為316.7±129.2ng/ml、40.2±30.1ng/ml 和12.0±4.9，三者均顯著高于體檢人群（156.0±63.8ng/ml，15.9±11.1ng/ml 和9.7±4.3）（P<0.05）。如果以體檢人群95%的可信區間設定正常參攷值，則PGⅠ、PGⅡ和PGⅠ/PGⅡ的參攷值分彆為<270.9ng/ml、<37.8n g/m l和<14.4，它們對胃潰瘍的暘性預期值分彆為61.7%、55.8%和13.3%。結論：胃潰瘍患者血清P GⅠ和P GⅡ水平均顯著高于體檢者，因此它們可能用于大規模人群胃潰瘍的篩查。
목적：：탐토위단백매원Ⅰ（P GⅠ）화위단백매원Ⅱ（P GⅡ）검측대위궤양환자적사사작용。방법：선취2013년1월-10월재청포중심의원적체검자2052례，위궤양환자120례，분별검측혈청P GⅠ화P GⅡ，병계산P GⅠ/P GⅡ비치，통계학분석삼개지표재체검자여위궤양환자지간적차이。결과：위궤양환자혈청PGⅠ、PGⅡ화PGⅠ/PGⅡ분별위316.7±129.2ng/ml、40.2±30.1ng/ml 화12.0±4.9，삼자균현저고우체검인군（156.0±63.8ng/ml，15.9±11.1ng/ml 화9.7±4.3）（P<0.05）。여과이체검인군95%적가신구간설정정상삼고치，칙PGⅠ、PGⅡ화PGⅠ/PGⅡ적삼고치분별위<270.9ng/ml、<37.8n g/m l화<14.4，타문대위궤양적양성예기치분별위61.7%、55.8%화13.3%。결론：위궤양환자혈청P GⅠ화P GⅡ수평균현저고우체검자，인차타문가능용우대규모인군위궤양적사사。
Objective: To investigate the screening effect of pepsinogenⅠ (PGⅠ) and epsinogenⅡ(PGⅡ) detection on gastric ulcer patients. Methods: 2052 physical examination population and 120 gastric ulcer patients were selected for PGⅠand PGⅡ detection in XXX hospital,from January 2011 to October 2011. Results: Serum PGⅠ, PGⅡ, and PGⅠ/PGⅡ in physical examination population were 316.7±129.2ng/ml, 40.2±30.1ng/ml, and 12.0±4.9, respectively. Each was significantly higher than those in gastric ulcer patients (156.0±63.8ng/ml, 5.9±11.1ng/ml, and 9.7±4.3,respectively.)(P<0.05). If PGⅠ<270.9 ng/ml as a reference, Positive expectations to gastric ulcer was 61.7%; PGⅡ<37.8ng/ml as a reference, Positive expectations to gastric ulcer was 55.8%; PGⅠ/PGⅡ<14.4 as a reference, Positive expectations to gastric ulcer was 13.3%. Conclusion: Serum PGⅠ and PGⅡ in gastric ulcers was significantly higher than those in physical examination population. Therefore, they may be useful in screening of gastric ulcer patients in large populations.
