CAJ | 학술논문

目的：探讨舍曲林和西酞普兰对抑郁症患者生活质量的影响。方法将60例抑郁症患者随机分为两组，每组各30例。分别给予舍曲林和西酞普兰治疗。以生活质量综合问卷（GQLT-74）、汉米尔顿抑郁量表（HAMD）评定两组患者生活质量的改变及抑郁状况。结果治疗2个月末时，两组治疗抑郁症疗效相当，西酞普兰副反应少于舍曲林；西酞普兰对抑郁症患者生活质量各维度的影响均具有显著性(P<0.01)。舍曲林除使心理功能和社会功能有所提高外，对躯体功能等均无显著改善( P>0.05)。结论西酞普兰组与舍曲林组相比，西酞普兰更能改善抑郁症患者的生活质量。
목적：탐토사곡림화서태보란대억욱증환자생활질량적영향。방법장60례억욱증환자수궤분위량조，매조각30례。분별급여사곡림화서태보란치료。이생활질량종합문권（GQLT-74）、한미이돈억욱량표（HAMD）평정량조환자생활질량적개변급억욱상황。결과치료2개월말시，량조치료억욱증료효상당，서태보란부반응소우사곡림；서태보란대억욱증환자생활질량각유도적영향균구유현저성(P<0.01)。사곡림제사심리공능화사회공능유소제고외，대구체공능등균무현저개선( P>0.05)。결론서태보란조여사곡림조상비，서태보란경능개선억욱증환자적생활질량。
Objective :To explore the effects of Sertraline and Citalopram the social function and life quality of the depressive disorder Citalopram. Methods :60 depressive disorder that are consistent with the diagnostic criteria of depression in ICD-10 were divide drandomly into two groups and treated with Sertraline and Citalopram, respectively . Each group of 30 cases. Before and after the treatment, the depress symptoms were evaluated by HAMD and the life quality was evaluated by GQOLI-74,Results :The curative effect of improving depression symptoms in Citalopram group was equivalent with that of Sertraline group in the end of 2 month treatment. After 2 months treatment, the Citalopram group improved obviously the life quality ( P < 0. 01) , While Sertraline group did not improve the life quality except mental function factor and Social function ( P > 0. 05) . Conclusions :Citalopram is more useful for improving he life quality of the depressive disorder than Sertraline.