CAJ | 학술논문

目的：研究丙戊酸钠（VPA）对癫痫患儿体重的影响及其机制。方法按照纳入标准收集泸州医学院附属医院神经内科门诊2011年5月-2013年5月首次诊断癫痫后VPA单药治疗的患儿48例作为实验组，于治疗前、治疗后1、3、6个月检测患儿体质量指数(BMI)及血清瘦素水平。另选择健康儿童24例作为对照组。结果实验组治疗后1、3、6个月BMI及血清瘦素均呈现出上升趋势，且两者在各时间点均明显高于对照组，差异有统计学意义(P<0.05)。结论 VPA可增加癫痫患儿体重，其机制可能与显著上调血清瘦素水平有关。
목적：연구병무산납（VPA）대전간환인체중적영향급기궤제。방법안조납입표준수집로주의학원부속의원신경내과문진2011년5월-2013년5월수차진단전간후VPA단약치료적환인48례작위실험조，우치료전、치료후1、3、6개월검측환인체질량지수(BMI)급혈청수소수평。령선택건강인동24례작위대조조。결과실험조치료후1、3、6개월BMI급혈청수소균정현출상승추세，차량자재각시간점균명현고우대조조，차이유통계학의의(P<0.05)。결론 VPA가증가전간환인체중，기궤제가능여현저상조혈청수소수평유관。
Objective To study the effect of valproic acid (VPA) on the body weight of pediatric patients with epilepsy and its mechanism. Methods 48 pediatric patients first diagnosed with epilepsy in Neurology Clinic of The Affiliated Hospital of Luzhou Medical College and treated with VPA from May, 2011 to May, 2013 were selected as the experimental group according to the in-clusion criteria. The parameters of body mass index (BMI) and the serum content of leptin of them were detected before treatment and at 1, 3, 6 months after treatment. And 24 healthy children were selected as the control group. Results The BMI and the serum leptin of the experimental group both showed uptrend at 1, 3, 6 months after treatment, which were significantly higher than those of the control group at the same time point, the differences were statistically significant ( P<0.05). Conclusion VPA can significant-ly increase the body weight of pediatric patients with epilepsy, and it may be related to the up-regulation of the serum leptin level.