CAJ | 학술논문

目的：探讨同型半胱氨酸在不同疾病中的临床意义。方法：收治住院患者247例，根据临床诊断分为高血压组、糖尿病组、心梗组、脑梗组、肾病组。对所有入组患者分别检测Hcy、TC、TG、HDL和LDL。结果：各病例组男、女Hcy值与对照组男、女相比，差异有统计学意义(P＜0.01)。各组TG和HDL水平与对照组相比，差异有统计学意义(P＜0.05)。5组病例中，男性Hcy值均高于女性，除高血压组男、女Hcy值差异无统计学意义(P＞0.05)外，糖尿病组、心梗组、脑梗组、肾病组男女间Hcy值差异均有统计学意义(P＜0.05)。各组间女性Hcy值升高程度差异无统计学意义(P＞0.05)；男性心梗组、脑梗组 Hcy 值与糖尿病组、高血压组和肾病组差异有统计学意义(P＜0.05)。高血压组、糖尿病组、心梗组、脑梗组和肾病组 Hcy 水平与 TC、TG、LDL 无相关，与 HDL 水平降低有相关性(P＜0.05)。结论：Hcy列入上述疾病的常规检查和定期体检，做到早发现、早预防和早治疗，以减少心脑血管的危害。
목적：탐토동형반광안산재불동질병중적림상의의。방법：수치주원환자247례，근거림상진단분위고혈압조、당뇨병조、심경조、뇌경조、신병조。대소유입조환자분별검측Hcy、TC、TG、HDL화LDL。결과：각병례조남、녀Hcy치여대조조남、녀상비，차이유통계학의의(P＜0.01)。각조TG화HDL수평여대조조상비，차이유통계학의의(P＜0.05)。5조병례중，남성Hcy치균고우녀성，제고혈압조남、녀Hcy치차이무통계학의의(P＞0.05)외，당뇨병조、심경조、뇌경조、신병조남녀간Hcy치차이균유통계학의의(P＜0.05)。각조간녀성Hcy치승고정도차이무통계학의의(P＞0.05)；남성심경조、뇌경조 Hcy 치여당뇨병조、고혈압조화신병조차이유통계학의의(P＜0.05)。고혈압조、당뇨병조、심경조、뇌경조화신병조 Hcy 수평여 TC、TG、LDL 무상관，여 HDL 수평강저유상관성(P＜0.05)。결론：Hcy렬입상술질병적상규검사화정기체검，주도조발현、조예방화조치료，이감소심뇌혈관적위해。
Objective:To explore the clinical significance of homocysteine in different diseases.Methods:247 inpatients were selected.According to the clinical diagnosis,they were divided into hypertension group,diabetes group,myocardial infarction group, cerebral infarction group and nephropathy group.HCY,TC,TG,HDL and LDL of all patients were respectively detected.Results:The HCY value of male and female of all the case groups was compared with the male and female of the control group,the difference was statistically significant(P<0.01).TG and HDL of all the case groups were compared with the control group,the difference was statistically significant(P<0.05).In 5 case groups,HCY value of male were higher than female;in the hypertension group,the difference of HCY value between male and female was not statistically significant(P>0.05);in diabetes group, myocardial infarction group,cerebral infarction group and nephropathy group,the differences of HCY value between male and female were statistically significant(P<0.05).The female HCY value elevated level of each group had no significant difference(P>0.05);HCY values of male myocardial infarction group,cerebral infarction group had significant difference with diabetes group, hypertension group,and nephropathy group(P<0.05).The levels of HCY of hypertension group,diabetes group,myocardial infarction group,cerebral infarction group and nephropathy group had no correlation with TC,TG and LDL,and had correlation with decreased HDL levels(P<0.05).Conclusion:HCY should be listed in routine inspection and regular physical examination of the above diseases in order to achieve early discovery,early prevention and early treatment,so as to reduce the harm of cardiovascular and cerebrovascular diseases.