中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
14期
115-115,118
,共2页
肿瘤标记物%神经母细胞瘤%神经特异性烯醇化酶%乳酸脱氢酶%S100蛋白
腫瘤標記物%神經母細胞瘤%神經特異性烯醇化酶%乳痠脫氫酶%S100蛋白
종류표기물%신경모세포류%신경특이성희순화매%유산탈경매%S100단백
Tumor markers%Neuroblastoma%Neuron specific enolase%Lactate dehydrogenase%S100 protein
目的:探讨神经母细胞瘤患者血清肿瘤标记物围手术期的变化及其临床意义。方法:收治神经母细胞瘤患者52例,对其临床资料进行回顾性分析,并分析其血清肿瘤标记物,血清神经元特异性烯醇化酶(neurone specific enolase,NSE)、乳酸脱氢酶(lactic dehydrogenase,LDH)、S100蛋白手术前后的变化及相关关系。结果:52例初诊患者的血清 NSE 为33~356μg/L,血清 LDH 水平251~806U/L,手术后血清 NSE 为9~125μg/L,血清 LDH 水平101~320U/L,与手术前比较差异有统计学意义(P<0.01)。NSE与LDH呈正相关(r=0.593,P<0.01)。结论:NSE、LDH反映肿瘤负荷,其可作为手术前后监测神经母细胞瘤疗效的辅助性指标。
目的:探討神經母細胞瘤患者血清腫瘤標記物圍手術期的變化及其臨床意義。方法:收治神經母細胞瘤患者52例,對其臨床資料進行迴顧性分析,併分析其血清腫瘤標記物,血清神經元特異性烯醇化酶(neurone specific enolase,NSE)、乳痠脫氫酶(lactic dehydrogenase,LDH)、S100蛋白手術前後的變化及相關關繫。結果:52例初診患者的血清 NSE 為33~356μg/L,血清 LDH 水平251~806U/L,手術後血清 NSE 為9~125μg/L,血清 LDH 水平101~320U/L,與手術前比較差異有統計學意義(P<0.01)。NSE與LDH呈正相關(r=0.593,P<0.01)。結論:NSE、LDH反映腫瘤負荷,其可作為手術前後鑑測神經母細胞瘤療效的輔助性指標。
목적:탐토신경모세포류환자혈청종류표기물위수술기적변화급기림상의의。방법:수치신경모세포류환자52례,대기림상자료진행회고성분석,병분석기혈청종류표기물,혈청신경원특이성희순화매(neurone specific enolase,NSE)、유산탈경매(lactic dehydrogenase,LDH)、S100단백수술전후적변화급상관관계。결과:52례초진환자적혈청 NSE 위33~356μg/L,혈청 LDH 수평251~806U/L,수술후혈청 NSE 위9~125μg/L,혈청 LDH 수평101~320U/L,여수술전비교차이유통계학의의(P<0.01)。NSE여LDH정정상관(r=0.593,P<0.01)。결론:NSE、LDH반영종류부하,기가작위수술전후감측신경모세포류료효적보조성지표。
Objective:To explore the changes of serum tumor markers of Neuroblastoma in the peri-operation period and its clinical significance.Methods:We selected 52 cases of neuroblastoma patients.Their clinical data were retrospectively analyzed, and we analyzed the changes of serum tumor marker,serum neuron specific enolase,lactate dehydrogenase,S100 protein before and after treatment and their relationship.Results:In 52 patients,before surgery,serum NSE was 33 to 356(271)μg/L,and serum LDH level was 251 to 806(563)U/L.After operation,serum NSE was 9 to 125(19)μg/L,and serum LDH level was 101 to 320(162) U/L.Compared with before the operation,the difference was statistically significant(P<0.01).NSE was positively correlated with LDH (r=0.593,P<0.01).Conclusion:NSE,LDH can accurately reflect the tumor load,so they can be used as auxiliary indexes to monitor neuroblastoma effect before and after operation.