现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
14期
2116-2117,2119
,共3页
关节炎,类风湿%颈动脉%动脉粥样硬化%危险因素%超声检查
關節炎,類風濕%頸動脈%動脈粥樣硬化%危險因素%超聲檢查
관절염,류풍습%경동맥%동맥죽양경화%위험인소%초성검사
Arthritis,rheumatoid%Carotid arteries%Atherosclerosis%Risk factors%Ultrasonography
目的：探讨类风湿关节炎（RA）与颈动脉粥样硬化症（CAS）的相关性。方法将该院2010年6月至2013年6月诊治的RA患者130例（RA组），根据改良的疾病活动性评分分为4个亚组（RA1、RA2、RA3、RA4），选择同期健康体检者96例作为对照组。分析各组颈动脉内膜增厚情况及颈动脉斑块数量，并探讨CAS相关性因素。结果 RA组患者CAS发生率高于对照组，差异有统计学意义（P<0.05），但缓解期患者CAS检出率与对照组比较，差异无统计学意义（P＞0.05），活动期患者发生CAS检出率明显高于对照组，差异有统计学意义（P<0.01）。进行Logistic回归分析，发现类风湿因子滴度、年龄、红细胞沉降率、C-反应蛋白是CAS的危险因素。结论 RA与CAS的发生和发展关系密切。
目的：探討類風濕關節炎（RA）與頸動脈粥樣硬化癥（CAS）的相關性。方法將該院2010年6月至2013年6月診治的RA患者130例（RA組），根據改良的疾病活動性評分分為4箇亞組（RA1、RA2、RA3、RA4），選擇同期健康體檢者96例作為對照組。分析各組頸動脈內膜增厚情況及頸動脈斑塊數量，併探討CAS相關性因素。結果 RA組患者CAS髮生率高于對照組，差異有統計學意義（P<0.05），但緩解期患者CAS檢齣率與對照組比較，差異無統計學意義（P＞0.05），活動期患者髮生CAS檢齣率明顯高于對照組，差異有統計學意義（P<0.01）。進行Logistic迴歸分析，髮現類風濕因子滴度、年齡、紅細胞沉降率、C-反應蛋白是CAS的危險因素。結論 RA與CAS的髮生和髮展關繫密切。
목적：탐토류풍습관절염（RA）여경동맥죽양경화증（CAS）적상관성。방법장해원2010년6월지2013년6월진치적RA환자130례（RA조），근거개량적질병활동성평분분위4개아조（RA1、RA2、RA3、RA4），선택동기건강체검자96례작위대조조。분석각조경동맥내막증후정황급경동맥반괴수량，병탐토CAS상관성인소。결과 RA조환자CAS발생솔고우대조조，차이유통계학의의（P<0.05），단완해기환자CAS검출솔여대조조비교，차이무통계학의의（P＞0.05），활동기환자발생CAS검출솔명현고우대조조，차이유통계학의의（P<0.01）。진행Logistic회귀분석，발현류풍습인자적도、년령、홍세포침강솔、C-반응단백시CAS적위험인소。결론 RA여CAS적발생화발전관계밀절。
Objective To study the relevancy of rheumatoid arthritis (RA) and carotid atherosclerosis (CAS). Methods A total of 130 patients with RA(RA group),who were received in the hospital from June 2010 to June 2013,were divided into 4 subgroups(RA1,RA2,RA3 and RA4) according the modified disease activity score-28(DAS28),simultaneously,other 96 health subjects were selected as control group. The amounts of carotid artery intima media thickness and carotid arteriosclerosis plaques in all the groups were analyzed ,and the interrelated factors of CAS were disucssed. Results The occurrence rate of patients with CAS in RA group was significantly higher than that of the people in the control group (P<0.05),but there was no statistically signif icant difference between the RA patients in remission stage and the people in control group on the occurrence of CAS (P>0.05), and the detection rate of CAS of the RA patients in active stage was obviously higher than that of the people in the control group (P<0.01). The Logistic analysis of the regression showed that the rheumatoid factors titer,age,erythrocyte sedimentation rate,C reactive protein were risk factors for CAS. Conclusion RA is closely related to the occurrence and development of CAS.
