中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
22期
38-38,40
,共2页
幽门螺杆菌%阿莫西林%奥美拉唑%克拉霉素%左氧氟沙星%甲硝唑
幽門螺桿菌%阿莫西林%奧美拉唑%剋拉黴素%左氧氟沙星%甲硝唑
유문라간균%아막서림%오미랍서%극랍매소%좌양불사성%갑초서
Helicobacter pylori%Amoxicillin%Omeprazole%Clarithromycin%Levofloxacin%Metronidazole
目的：探讨奥美拉唑、阿莫西林联合克拉霉素与奥美拉唑、左氧氟沙星联合甲硝唑两种三联疗法根除幽门螺杆菌(Hp)阳性消化性溃疡临床疗效差异。方法：2013年5月-2014年5月收治幽门螺杆菌阳性消化性溃疡患者170例，随机分成奥美拉、阿莫西林联合克拉霉素组(A组)和奥美拉唑、左氧氟沙星联合甲硝唑组(B组)各85例，A组：奥美拉唑片20 mg/次，2次/日；阿莫西林胶囊110 g/次，2次/日；克拉霉素0.15 g/次，2次/日；于饭后服用，疗程1周。后继续单独给予奥美拉唑片20 mg/次，2次/日，连续给药7～10天。B组：奥美拉唑片20 mg/次，2次/日；左氧氟沙星0.2 g/次，甲硝唑0.4 g/次，2次/日，饭后服用，疗程1周。结果：A组痊愈42例，显效30例，好转11例，无效2例，总有效率97.6%。B组痊愈41例，显效31例，好转10例，无效3例，总有效率96.5%。两组疗效比较差异无统计学意义(P＞0.05)，A组根除Hp80例，根除率90.9%，B组根除Hp77例，根除率90.6%，两组比较差异无统计学意义(P＞0.05)。结论：两种三联疗法根除幽门螺杆菌阳性消化性溃疡疗效无显著性差异，可根据患者的情况给予治疗。
目的：探討奧美拉唑、阿莫西林聯閤剋拉黴素與奧美拉唑、左氧氟沙星聯閤甲硝唑兩種三聯療法根除幽門螺桿菌(Hp)暘性消化性潰瘍臨床療效差異。方法：2013年5月-2014年5月收治幽門螺桿菌暘性消化性潰瘍患者170例，隨機分成奧美拉、阿莫西林聯閤剋拉黴素組(A組)和奧美拉唑、左氧氟沙星聯閤甲硝唑組(B組)各85例，A組：奧美拉唑片20 mg/次，2次/日；阿莫西林膠囊110 g/次，2次/日；剋拉黴素0.15 g/次，2次/日；于飯後服用，療程1週。後繼續單獨給予奧美拉唑片20 mg/次，2次/日，連續給藥7～10天。B組：奧美拉唑片20 mg/次，2次/日；左氧氟沙星0.2 g/次，甲硝唑0.4 g/次，2次/日，飯後服用，療程1週。結果：A組痊愈42例，顯效30例，好轉11例，無效2例，總有效率97.6%。B組痊愈41例，顯效31例，好轉10例，無效3例，總有效率96.5%。兩組療效比較差異無統計學意義(P＞0.05)，A組根除Hp80例，根除率90.9%，B組根除Hp77例，根除率90.6%，兩組比較差異無統計學意義(P＞0.05)。結論：兩種三聯療法根除幽門螺桿菌暘性消化性潰瘍療效無顯著性差異，可根據患者的情況給予治療。
목적：탐토오미랍서、아막서림연합극랍매소여오미랍서、좌양불사성연합갑초서량충삼련요법근제유문라간균(Hp)양성소화성궤양림상료효차이。방법：2013년5월-2014년5월수치유문라간균양성소화성궤양환자170례，수궤분성오미랍、아막서림연합극랍매소조(A조)화오미랍서、좌양불사성연합갑초서조(B조)각85례，A조：오미랍서편20 mg/차，2차/일；아막서림효낭110 g/차，2차/일；극랍매소0.15 g/차，2차/일；우반후복용，료정1주。후계속단독급여오미랍서편20 mg/차，2차/일，련속급약7～10천。B조：오미랍서편20 mg/차，2차/일；좌양불사성0.2 g/차，갑초서0.4 g/차，2차/일，반후복용，료정1주。결과：A조전유42례，현효30례，호전11례，무효2례，총유효솔97.6%。B조전유41례，현효31례，호전10례，무효3례，총유효솔96.5%。량조료효비교차이무통계학의의(P＞0.05)，A조근제Hp80례，근제솔90.9%，B조근제Hp77례，근제솔90.6%，량조비교차이무통계학의의(P＞0.05)。결론：량충삼련요법근제유문라간균양성소화성궤양료효무현저성차이，가근거환자적정황급여치료。
Objective:To investigate differences of the clinical efficacy of two kinds of triple therapy:omeprazole,amoxicillin combined with clarithromycin and omeprazole,levofloxacin combined with metronidazole in eradication of Helicobacter Pylori Positive Peptic ulcer.Methods:170 cases with Helicobacter pylori positive peptic ulcer were selected from May 2013 to May 2014. They were randomly divided into the omeprazole, amoxicillin combined with clarithromycin group(A group) and omeprazole, levofloxacin combined with metronidazole group(B group) with 85 cases in each.A group:Omeprazole tablets 20 mg/time,2times/day;Amoxicillin Capsules 110 g/time,2times/day;clarithromycin 0.15 g/time,2times/day;after meals,the course of treatment was 1 week.Then continue to give omeprazole tablets 20 mg/time,2times/day,administered continuously for 7~10 days.B group:Omeprazole tablets 20 mg/time,2times/day;Levofloxacin 0.2 g/time,metronidazole 0.4 g/time,2 times/day,after meals,for 1 weeks. Results:In A group,42 cases were cured;30 cases were markedly effective;11 cases were improved;2 cases were ineffective;the total efficiency was 97.6%.In B group:41 cases were cured;31 cases were markedly effective;10 cases were improved;3 cases were ineffective;the total efficiency was 96.5%.There was no significant difference in efficacy between two groups(P>0.05).In A group:80 cases of Hp were eradicated,and the eradication rate was 90.9%.In B group:77 cases of HP were eradicated,and the eradication rate was 90.6%.The two groups had no significant difference(P>0.05).Conclusion:The two kinds of triple therapies for eradication of Helicobacter pylori positive peptic ulcer without significant difference.We can treat them according to the condition of the patients.
