CAJ | 학술논문

目的：探讨和分析采用131I治疗甲亢患者后继发早发甲低的临床因素。方法回顾性分析本院2011年03月至2013年03月本院收治的采用131I治疗甲亢患者临床资料，治疗后定期随访，根据是否继发甲低将患者分成甲低组与非甲低组，通过统计学处理分析两组患者在年龄、性别、病程、治疗前甲状腺质量、131I剂量、治疗前后甲状腺功能、计划给予每克甲状腺组织的摄取剂量、是否接受过内科药物治疗等因素与甲低的关系。结果随访1年后，23.15%（50/216）患者治疗后继发甲低，76.85%（166/216）患者甲状腺恢复正常，两组患者在131I剂量上无显著性差异(P>0.05)，但两组患者在每克组织给予的摄取剂量间差异存在显著性差异(P<0.05)。结论临床研究结果表明采用131I治疗甲亢时继发甲低与患者每克组织摄取的131I量密切相关，临床上可以通过适当调整131I的给药量来减少和避免早发甲低的发生。
목적：탐토화분석채용131I치료갑항환자후계발조발갑저적림상인소。방법회고성분석본원2011년03월지2013년03월본원수치적채용131I치료갑항환자림상자료，치료후정기수방，근거시부계발갑저장환자분성갑저조여비갑저조，통과통계학처리분석량조환자재년령、성별、병정、치료전갑상선질량、131I제량、치료전후갑상선공능、계화급여매극갑상선조직적섭취제량、시부접수과내과약물치료등인소여갑저적관계。결과수방1년후，23.15%（50/216）환자치료후계발갑저，76.85%（166/216）환자갑상선회복정상，량조환자재131I제량상무현저성차이(P>0.05)，단량조환자재매극조직급여적섭취제량간차이존재현저성차이(P<0.05)。결론림상연구결과표명채용131I치료갑항시계발갑저여환자매극조직섭취적131I량밀절상관，림상상가이통과괄당조정131I적급약량래감소화피면조발갑저적발생。
Objective To investigate and analysis the clinical factors in patients with secondary hypothyroidism after 131I therapy for hyperthyroidism. Methods a retrospective analysis of our hospital in 2011 03 to 2013 03 months in the hospital clinical data of131I treatment for hyperthyroidism, regular folow-up after treatment, according to whether the patients were divided into secondary hypothyroidism hypothyroidism group and non hypothyroidism group, through statistical analysis of two groups in age, sex, course of disease, before and after the treatment of thyroid mass,131I dose, treatment of thyroid function, plan to give the ingestion dose per gram of thyroid tissue, whether the relationship between drug treatment received Department of internal medicine and factors such as hypothyroidism. After 1 years of folow-up results, 23.15% (50/216) subsequent hypothyroidism patients, 76.85% (166/216) in patients with thyroid returned to normal, the two groups had no significant difference in 131I dose (P>0.05), but there was significant difference between two groups of patients treated in the absorption dose per gram of tissue (P<0.05). Conclusion the clinical research results show that the 131I treatment of hyperthyroidism is closely related to131I and secondary hypothyroidism patients per gram of tissue uptake by, clinical on can by adjusting the dosage of 131I to reduce and avoid the occurrence of early hypothyroidism.