CAJ | 학술논문

目的：探讨广州民警血清尿酸（ UA）水平与高血压及心电图缺血性ST-T改变的关系。方法广州市海珠区公安民警2120例，按照血清UA水平分为4个组：UA＜349μmol/L为低水平组，UA 349～408μmol/L为中等较低水平组，UA 409～472μmol/L为中等较高水平组，UA＞472μmol/L为高水平组。比较各组血压、心电图缺血性ST-T改变及TG、CHOL、LDL-C、HDL-C、空腹血糖（ FBG ）、ALT、AST、UA、肌酐（ CRE ）水平。结果高血压335例，UA水平为（445．6±99．2）μmol/L；非高血压1785例，UA水平为（406．6±93．5）μmol/L；P＜0．01。无心电图缺血性ST-T改变1938例，UA水平为（414．9±93．9）μmol/L；有缺血性ST-T改变182例，UA水平为（386．0±106．1）μmol/L；P＜0．01。多因素非条件性Logistic回归分析发现，年龄、Hb、RBC、ALT、TG、UA、ST-T改变、B超脂肪肝表现可能是高血压病的危险因素；DBP、GLU、AST可能是心电图缺血性ST-T改变的危险因素。结论广州市海珠区公安民警血压水平及高血压病发病率随UA水平升高而升高，UA可能是高血压病独立危险因素。 UA在低水平及高水平可能导致心电图缺血性ST-T改变发生率升高；但当UA达到一定高水平后，心电图缺血性ST-T改变发生率可能有所回落。
목적：탐토엄주민경혈청뇨산（ UA）수평여고혈압급심전도결혈성ST-T개변적관계。방법엄주시해주구공안민경2120례，안조혈청UA수평분위4개조：UA＜349μmol/L위저수평조，UA 349～408μmol/L위중등교저수평조，UA 409～472μmol/L위중등교고수평조，UA＞472μmol/L위고수평조。비교각조혈압、심전도결혈성ST-T개변급TG、CHOL、LDL-C、HDL-C、공복혈당（ FBG ）、ALT、AST、UA、기항（ CRE ）수평。결과고혈압335례，UA수평위（445．6±99．2）μmol/L；비고혈압1785례，UA수평위（406．6±93．5）μmol/L；P＜0．01。무심전도결혈성ST-T개변1938례，UA수평위（414．9±93．9）μmol/L；유결혈성ST-T개변182례，UA수평위（386．0±106．1）μmol/L；P＜0．01。다인소비조건성Logistic회귀분석발현，년령、Hb、RBC、ALT、TG、UA、ST-T개변、B초지방간표현가능시고혈압병적위험인소；DBP、GLU、AST가능시심전도결혈성ST-T개변적위험인소。결론엄주시해주구공안민경혈압수평급고혈압병발병솔수UA수평승고이승고，UA가능시고혈압병독립위험인소。 UA재저수평급고수평가능도치심전도결혈성ST-T개변발생솔승고；단당UA체도일정고수평후，심전도결혈성ST-T개변발생솔가능유소회락。
Objective To discuss the relationships between uric acid ( UA) and hypertension or electrocardiogram is-chemic ST-T changes of Guangzhou policemen .Methods Totally 2 120 policemen of Haizhu District of Guangzhou were di-vided into four groups according to their UA levels as following: UA<349 μmol/L was the low level group , UA 349-408μmol/L was the medium relatively low group , UA 409-472μmol/L was the medium relatively high level group and UA >472μmol/L was the high level group .The blood pressure, the incidence of ECG ischemic ST-T changes, TG, CHOL, LDL-C, HDL-C, fast blood glucose (FBG), ALT, AST, UA, creatinine (CRE) levels between those groups were compared and ana-lyzed.Results There were 335 cases suffering hypertension , whose UA levels were (445.6 ±99.2) μmol/L; and there were 1 785 cases without hypertension , whose UA levels were (406.6 ±93.5)μmol/L (P<0.01).There were 1 938 cases without ischemic ECG ST-T changes, whose UA levels were (414.9 ±93.9) μmol/L;and there were 182 cases with ische-mic ECG ST-T changes, whose UA levels were (386.0 ±106.1) μmol/L;P<0.01.Multivariate unconditional logistic re-gression analysis suggested that age , Hb, RBC, ALT, TG, UA, ST-T changes and fatty liver of B ultrosound all might be the risk factors for hypertension;DBP, GLU and AST might be the risk factors for ischemic ECG ST-T changes.Conclusions Both of the blood pressure levels and prevalence of hypertension rise with the increase of UA levels .UA may be an independ-ent factor for hypertension .Either of the low levels or high levels of UA may increase the incidence of ECG ischemic ST -T changes.But when UA reaches a certain high level , the incidence of ECG ischemic ST-T changes may decline.