CAJ | 학술논문

目的：观察阿尔茨海默病（ AD）患者血浆淀粉样变程度、血清总胆固醇水平及全血黏度变化，并分析其相关性。方法 AD患者30例（观察组），健康对照人群30例（对照组），采用FL F-2500荧光分光光度计检测淀粉样纤维荧光强度，计算淀粉样纤维水平；LBY-N6A血流变仪检测血液流变学指标；TBA-120FR全自动生化仪检测血脂。多元线性回归分析法分析血浆淀粉样变程度、全血黏度（高切）、血清总胆固醇间的关系。结果观察组及对照组血浆淀粉样纤维水平分别为（16．63±5．67）、（12．83±0．27） U/mL，血清总胆固醇水平分别为（4．71±1．24）、（3．95±0．22）mmol/L，全血黏度（高切）水平分别为（4．16±0．54）、（3．74±0．15）mPa· s，两组比较，P均＜0．05。多元线性回归分析显示，血浆淀粉样变程度、血清总胆固醇水平与全血黏度（高切）呈正相关趋势（ r分别为0．598、0．664，P均＜0．05）。结论 AD患者血浆淀粉样变程度、血清总胆固醇水平、全血黏度升高，前两者与后者呈正相关。
목적：관찰아이자해묵병（ AD）환자혈장정분양변정도、혈청총담고순수평급전혈점도변화，병분석기상관성。방법 AD환자30례（관찰조），건강대조인군30례（대조조），채용FL F-2500형광분광광도계검측정분양섬유형광강도，계산정분양섬유수평；LBY-N6A혈류변의검측혈액류변학지표；TBA-120FR전자동생화의검측혈지。다원선성회귀분석법분석혈장정분양변정도、전혈점도（고절）、혈청총담고순간적관계。결과관찰조급대조조혈장정분양섬유수평분별위（16．63±5．67）、（12．83±0．27） U/mL，혈청총담고순수평분별위（4．71±1．24）、（3．95±0．22）mmol/L，전혈점도（고절）수평분별위（4．16±0．54）、（3．74±0．15）mPa· s，량조비교，P균＜0．05。다원선성회귀분석현시，혈장정분양변정도、혈청총담고순수평여전혈점도（고절）정정상관추세（ r분별위0．598、0．664，P균＜0．05）。결론 AD환자혈장정분양변정도、혈청총담고순수평、전혈점도승고，전량자여후자정정상관。
Objective To observe the plasma amyloidosis degree , serum total cholesterol level and whole blood vis-cosity changes in patients with Alzheimer's disease ( AD) , and to analyze their correlations .Methods Thirty cases of AD patients (observation group) and 30 cases of healthy controls (control group) were selected.The plasma amyloid fibril flu-orescence intensity was detected by FL F-2500 fluorospectro photometer , then we calculated the amyloid fibril levels;LBY-N6A rheology instrument was used to examine the hemorrheological parameters;and TBA-120FR automatic biochemical an-alyzer was used to test the blood lipid level .Multivariate linear regression analysis was used to analyze the relationships a-mong plasma amyloidosis degree , whole blood viscosity ( high shear part ) and serum total cholesterol .Results In the ob-servation group and control group , the plasma amyloid fibril levels were (16.63 ±5.67) and (12.83 ±0.27) U/mL, re-spectively;the whole blood viscosity (high) were (4.16 ±0.54) and (3.74 ±0.15) mPa· s, respectively;and the total cholesterol levels were (4.71 ±1.24) and (3.95 ±0.22) mmol/L, respectively (all P<0.05).The multivariate linear regression analysis showed whole blood viscosity ( high shear part ) was positively correlated with plasma amyloidosis degree and serum total cholesterol level (r=0.598, 0.664;all P<0.05).Conclusion Plasma amyloidosis degree, serum total cholesterol level and whole blood viscosity increase in AD patients , and the first two are positively correlated with the latter one.