CAJ | 학술논문

目的：探讨重型β-地中海贫血患儿治疗依从性与并发症发生关系。方法调查108例在本院治疗的重型β-地中海贫患儿输血、去铁治疗依从性情况及其与并发症发生的关系。结果输血依从性组66例患儿，非依从性组42例患儿；去铁治疗依从组73例患儿，非依从性组35例患儿。输血依从性组患儿生长发育停滞、特殊面容、肝脾肿大并发症发生率明显低于输血治疗非依从组，去铁治疗依从组患儿肝脏并发症、心脏并发症、内分泌功能损害并发症发生率明显低于去铁治疗非依从组，组间比较，均P＜0.01，差异具有统计学意义。结论重型β-地中海贫血患儿输血及去铁治疗依从性较低，治疗非依从性患儿其并发症发生率较高。
목적：탐토중형β-지중해빈혈환인치료의종성여병발증발생관계。방법조사108례재본원치료적중형β-지중해빈환인수혈、거철치료의종성정황급기여병발증발생적관계。결과수혈의종성조66례환인，비의종성조42례환인；거철치료의종조73례환인，비의종성조35례환인。수혈의종성조환인생장발육정체、특수면용、간비종대병발증발생솔명현저우수혈치료비의종조，거철치료의종조환인간장병발증、심장병발증、내분비공능손해병발증발생솔명현저우거철치료비의종조，조간비교，균P＜0.01，차이구유통계학의의。결론중형β-지중해빈혈환인수혈급거철치료의종성교저，치료비의종성환인기병발증발생솔교고。
Objective To explore the relationship of therapeutic compliance and complications in children with severeβ-thalassemia.Method One hundred and eight children with severeβ-thalassemia involved in the survey using convenient sampling to investigate the relationships between compliances with blood transfusion and iron removal treatment and complications.Results Of all the patients,66 complied with blood transfusion and the rest 42 did not;73 complied with the therapy and the rest 35 did not. Those complying with the blood transfusion had significant lower rates of developmental retardation,unusual faces,hepatosplenomegaly(P<0.01). Those complying with the therapy had significant lower rates of injuries in liver,heart and endocrinal system(P<0.01).Conclusion Therapeutic compliance in children with severeβ-thalassemia is at lower level so that the incidence of complications in them is higher.