CAJ | 학술논문

目的：回顾性分析不同年龄段女性乳腺癌的临床病理特征，探讨其发病特点，为不同年龄段女性乳腺癌临床诊治提供经验。方法整理并分析广州医科大学附属第一医院2001年1月至2005年12月确诊的123例不同年龄段女性乳腺癌的临床病理资料及相关免疫组化指标。结果123例乳腺癌患者中，青年组（≤35岁）女性乳腺癌占7.3％，中年组（>35~60岁）女性乳腺癌占67.5％，老年组（>60岁）女性乳腺癌占25.2％。青年组乳腺癌淋巴结转移率、肿瘤大小及组织学分级（Ⅱ/Ⅲ级）明显高于中、老年组，差异均有统计学意义（P<0．05），而中、老年组间比较，差异无统计学意义（P>0．05）。病理分型：全部乳腺癌中有非特殊类型乳腺癌101例，特殊类型乳腺癌22例；青年组乳腺癌9例全是非特殊浸润癌，而中年组非特殊浸润性乳腺癌占81.9%，老年组非特殊浸润性乳腺癌占77.4%，青年组非特殊浸润性乳腺癌占比明显高于中、老年组，但各组间比较，差异均无统计学意义（P>0．05）。免疫组化指标青年组乳腺癌表皮生长因子（VEGF）-C/VEGF-D的表达阳性率分别为100.0%和88.9%，高于中年组的77.1%和72.3%，以及老年组的70.9%和67.7%，但各组间VEGF-C/VEGF-D表达阳性率比较，差异均无统计学意义（P>0．05）。结论>35~60岁是女性乳腺癌发病高峰，青年组女性乳腺癌淋巴结转移率、肿瘤大小、组织学分级等临床病理特征及VEGF-C/-D表达阳性率均高于中、老年组，其恶性程度更高，临床处理需注意早期诊断和治疗。
목적：회고성분석불동년령단녀성유선암적림상병리특정，탐토기발병특점，위불동년령단녀성유선암림상진치제공경험。방법정리병분석엄주의과대학부속제일의원2001년1월지2005년12월학진적123례불동년령단녀성유선암적림상병리자료급상관면역조화지표。결과123례유선암환자중，청년조（≤35세）녀성유선암점7.3％，중년조（>35~60세）녀성유선암점67.5％，노년조（>60세）녀성유선암점25.2％。청년조유선암림파결전이솔、종류대소급조직학분급（Ⅱ/Ⅲ급）명현고우중、노년조，차이균유통계학의의（P<0．05），이중、노년조간비교，차이무통계학의의（P>0．05）。병리분형：전부유선암중유비특수류형유선암101례，특수류형유선암22례；청년조유선암9례전시비특수침윤암，이중년조비특수침윤성유선암점81.9%，노년조비특수침윤성유선암점77.4%，청년조비특수침윤성유선암점비명현고우중、노년조，단각조간비교，차이균무통계학의의（P>0．05）。면역조화지표청년조유선암표피생장인자（VEGF）-C/VEGF-D적표체양성솔분별위100.0%화88.9%，고우중년조적77.1%화72.3%，이급노년조적70.9%화67.7%，단각조간VEGF-C/VEGF-D표체양성솔비교，차이균무통계학의의（P>0．05）。결론>35~60세시녀성유선암발병고봉，청년조녀성유선암림파결전이솔、종류대소、조직학분급등림상병리특정급VEGF-C/-D표체양성솔균고우중、노년조，기악성정도경고，림상처리수주의조기진단화치료。
Objective To retrospectively analyze the clinicopathological characteristics of female breast cancer in differ-ent ages and explore the clinical characters ,in order to provide experience for the clinical diagnosis and treatment of female breast cancer in difference ages. Methods The clinicopathologic data and related immunohistochemical indicators of 123 female pa-tients female breast cancer in difference ages ,who were diagnosed from January 2001 to December 2005 in the First Affiliated Hospital of Guangzhou Medical University,were collected and analyzed. Results According to the age distribution,the youth group(with the age≤35 years) accounted for 7.3%of all the breast cancer patients;the middle-age group(with the age of 36-60 years) accounted for 67.5%;the elderly group(with the age>60 years) accounted for 25.2%. The metastases rate of lymph nodes in breast cancer,the tumor size and histological grade(gradeⅡ/Ⅲ) in the youth group were obviously higher than those in the middle-age group and elderly group with statistically significant difference (P<0.05),and the difference had no statistical significant be-tween the middle-age group and the elderly group(P>0.05). According to the pathological types,there were 101 cases of non-spe-cial invasive breast cancer from all the breast cancer patients and 22 cases of special invasive breast cancer;cases of breast cancer were non-special invasive cancer in the youth group ,and non-special invasive breast cancer accounted for 81.9%in the middle-age group and 77.4%in the elderly group ,while the proportion of non-special invasive breast cancer in the youth group was obvi-ously higher than the middle-age group and elderly group,but the comparison among the three groups had no statistically signifi-cant difference(P>0.05). The positive expression rates of vascular endothelial growth factor (VEGF)-C/VEGF-D in youth group were 100.0%and 88.9%respectively,which were higher than those in the middle-age group(77.1%and 72.3%) and elderly group (70.9%and 67.7%),and the differences among the three groups had statistically significant difference (P>0.05). Conclusion 36-60 years old is the peak age of female breast cancer ,and the clinical pathological characteristics including metastases rate of lymph nodes in breast cancer,tumor size and histological grade and the positive expression rate of VEGF-C/VEGF-D in the youth group are higher than those in the middle-age group and elderly group with greater likelihood of malignant ,so early diagnosis and treatment should be paid attention clinically.