现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
15期
2258-2259
,共2页
帕罗西汀%心力衰竭/外科学%抑郁症
帕囉西汀%心力衰竭/外科學%抑鬱癥
파라서정%심력쇠갈/외과학%억욱증
Paroxetine%Heart failure/surgery%Depressive disorder
目的：探讨帕罗西汀对慢性心力衰竭合并抑郁症患者的临床治疗疗效。方法将2010年1月至2012年6月52例伴抑郁症的慢性心力衰竭患者随机分为对照组和治疗组各26例，所有患者均给予常规抗心力衰竭治疗，治疗组在此基础上加用帕罗西汀抗抑郁治疗，疗程12周。分别于治疗前后测量和记录患者的左心室射血分数（LVEF）、生活质量（QOL）以及汉密尔顿抑郁量表-17（HAMD-17）评分，并计算抗抑郁治疗有效率。结果治疗组治疗后LVEF较对照组有明显提高，差异有统计学意义（P<0.05），QOL评分以及HAMD量表评分均有明显下降，差异均有统计学意义（P<0.05）。治疗组抗抑郁治疗总有效率达69.2%（18/26），对照组为38.5%（10/26），两组比较，差异有统计学意义（P<0.05）。结论帕罗西汀可以改善慢性心力衰竭合并抑郁症患者的抑郁症状，改善心功能，提高患者的QOL，值得临床推广。
目的：探討帕囉西汀對慢性心力衰竭閤併抑鬱癥患者的臨床治療療效。方法將2010年1月至2012年6月52例伴抑鬱癥的慢性心力衰竭患者隨機分為對照組和治療組各26例，所有患者均給予常規抗心力衰竭治療，治療組在此基礎上加用帕囉西汀抗抑鬱治療，療程12週。分彆于治療前後測量和記錄患者的左心室射血分數（LVEF）、生活質量（QOL）以及漢密爾頓抑鬱量錶-17（HAMD-17）評分，併計算抗抑鬱治療有效率。結果治療組治療後LVEF較對照組有明顯提高，差異有統計學意義（P<0.05），QOL評分以及HAMD量錶評分均有明顯下降，差異均有統計學意義（P<0.05）。治療組抗抑鬱治療總有效率達69.2%（18/26），對照組為38.5%（10/26），兩組比較，差異有統計學意義（P<0.05）。結論帕囉西汀可以改善慢性心力衰竭閤併抑鬱癥患者的抑鬱癥狀，改善心功能，提高患者的QOL，值得臨床推廣。
목적：탐토파라서정대만성심력쇠갈합병억욱증환자적림상치료료효。방법장2010년1월지2012년6월52례반억욱증적만성심력쇠갈환자수궤분위대조조화치료조각26례，소유환자균급여상규항심력쇠갈치료，치료조재차기출상가용파라서정항억욱치료，료정12주。분별우치료전후측량화기록환자적좌심실사혈분수（LVEF）、생활질량（QOL）이급한밀이돈억욱량표-17（HAMD-17）평분，병계산항억욱치료유효솔。결과치료조치료후LVEF교대조조유명현제고，차이유통계학의의（P<0.05），QOL평분이급HAMD량표평분균유명현하강，차이균유통계학의의（P<0.05）。치료조항억욱치료총유효솔체69.2%（18/26），대조조위38.5%（10/26），량조비교，차이유통계학의의（P<0.05）。결론파라서정가이개선만성심력쇠갈합병억욱증환자적억욱증상，개선심공능，제고환자적QOL，치득림상추엄。
Objective To explore the clinical effects of paroxetine in the treatment of patients with chronic heart failure (CHF) complicated with depression. Methods A total of 52 patients with CHF complicated with depression,who were hospital-ized in the department from January 2010 to June 2012 ,were randomly divided into control group and treatment group ,26 cases in each group. All the patients received conventional treatment for heart failure ,and the treatment group was added with paroxetine for anti-depression,12 weeks were regarded as a period. To determine the left ventricular ejection fraction (LVEF),the quality of life (QOL) and the Hamilton Depression Scale(HAMD) scores before and after treatment,and to calculate the effective rate of antide-pressive therapy. Results The LVEF in the treatment group improved more obviously than that in the control group (P<0.05);the QOL score and HAMD score in the treatment group decreased more significantly than those in the control group (P<0.05);the total effective rate of antidepressive therapy was 69.2%(18/26) in the treatment group and 38.5%(10/26) in the control group,and the difference between the two groups had statistically significant difference (P<0.05). Conclusion Paroxetine can improve de-pressive symptom of patients with chronic heart failure complicated with depression,increase cardiac function and enhance QOL, so it is worthy popularizing clinically.
