山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
31期
28-30
,共3页
病毒性疾病%心肌炎%白细胞介素-17%白细胞介素-35
病毒性疾病%心肌炎%白細胞介素-17%白細胞介素-35
병독성질병%심기염%백세포개소-17%백세포개소-35
viral disease%moycarditis%interleukin-17%interleukin-35
目的：观察病毒性心肌炎（ VMC）患者血清IL-17、IL-35水平变化，探讨其意义。方法选择70例VMC患者（ VMC组，其中急性期41例、恢复期29例）及30例健康查体者（对照组），采用ELISA法检测血清IL-17、IL-35水平，采用微粒子化学发光免疫分析法检测心肌肌钙蛋白I（ cTnI）水平，分析各指标相关性。结果 VMC组血清IL-17及cTnI水平均显著高于对照组、血清IL-35水平显著低于对照组，尤以急性期为著（P均＜0．05）。 VMC组血清IL-17和IL-35分别与cTnI水平呈正相关、负相关，r值分别为0．681、-0．583，P均＜0．05；血清IL-17与IL-35水平呈负相关，r＝-0．482，P＜0．01。结论 VMC患者血清IL-17与IL-35水平异常并与病情有关，两者可能共同参与了VMC的发生、发展。
目的：觀察病毒性心肌炎（ VMC）患者血清IL-17、IL-35水平變化，探討其意義。方法選擇70例VMC患者（ VMC組，其中急性期41例、恢複期29例）及30例健康查體者（對照組），採用ELISA法檢測血清IL-17、IL-35水平，採用微粒子化學髮光免疫分析法檢測心肌肌鈣蛋白I（ cTnI）水平，分析各指標相關性。結果 VMC組血清IL-17及cTnI水平均顯著高于對照組、血清IL-35水平顯著低于對照組，尤以急性期為著（P均＜0．05）。 VMC組血清IL-17和IL-35分彆與cTnI水平呈正相關、負相關，r值分彆為0．681、-0．583，P均＜0．05；血清IL-17與IL-35水平呈負相關，r＝-0．482，P＜0．01。結論 VMC患者血清IL-17與IL-35水平異常併與病情有關，兩者可能共同參與瞭VMC的髮生、髮展。
목적：관찰병독성심기염（ VMC）환자혈청IL-17、IL-35수평변화，탐토기의의。방법선택70례VMC환자（ VMC조，기중급성기41례、회복기29례）급30례건강사체자（대조조），채용ELISA법검측혈청IL-17、IL-35수평，채용미입자화학발광면역분석법검측심기기개단백I（ cTnI）수평，분석각지표상관성。결과 VMC조혈청IL-17급cTnI수평균현저고우대조조、혈청IL-35수평현저저우대조조，우이급성기위저（P균＜0．05）。 VMC조혈청IL-17화IL-35분별여cTnI수평정정상관、부상관，r치분별위0．681、-0．583，P균＜0．05；혈청IL-17여IL-35수평정부상관，r＝-0．482，P＜0．01。결론 VMC환자혈청IL-17여IL-35수평이상병여병정유관，량자가능공동삼여료VMC적발생、발전。
Objective To investigate the expression and its clinical significance of serum interleukin -17 ( IL-17 ) and interleukin-35(IL-35) in patients with viral moycarditis (VMC).Methods Seventy patients with VMC(VMC group, 41 in acute stage and 29 in remission stage ) and 30 healthy subjects ( control group ) were enrolled , Enzyme-linked immu-nosorbent assay(ELISA) was used to detect the blood serum level of IL-17 and IL-35, and chemiluminescent microparticle immunoassa was used to detect the blood serum level of cardiac troponin I (cTnI).The relationship among the indexes were analyzed.Results The serum level of IL-17 and cTnI in VMC group were both higher than those in the control group ,and the IL-35 was in the contrary, especially for the patients in acute stage ( all P<0.05).The serum level of IL-17 and IL-35 showed positive and negative corelation to the cTnI , r=0.681,-0.583( both P<0.05);IL-17 was negatively correlated to IL-35,r=-0.482,P<0.01.Conclusion The blood serum level of IL-17 and IL-35 in VMC patients is abnormal and correlated to the codition , these two indexes may be involved in the pathogenesis and development of VMC .
