CAJ | 학술논문

目的：分析正常妊娠与妊娠高血压综合征孕妇血浆D-二聚体水平差异，探讨高血压对妊娠期妇女D-二聚体水平的影响。方法：2010年3月-2013年10月收治妊娠期孕妇128例，按照是否合并高血压分为妊娠期高血压综合征组(60例)和正常妊娠组(68例)，另选择同期健康女性70例作为对照组。对比3组血浆D-二聚体水平。结果：妊娠高血压组、正常妊娠组D-二聚体水平显著高于对照组(P＜0.05，P＜0.01)。妊娠高血压组D-二聚体水平显著高于正常妊娠组(P＜0.05)；不同程度妊娠高血压之间血浆D-二聚体水平差异具有统计学意义(P＜0.05)。结论：正常妊娠者血浆D-二聚体含量增高，血液趋于高凝状态。妊娠高血压疾病患者伴有凝血系统的病理学改变，其血浆D-二聚体水平较正常妊娠更高。建议对妊娠高血压患者进行严格的血浆D-二聚体水平监测，以及时了解是否存在血栓性病变，有效保护母婴健康。
목적：분석정상임신여임신고혈압종합정잉부혈장D-이취체수평차이，탐토고혈압대임신기부녀D-이취체수평적영향。방법：2010년3월-2013년10월수치임신기잉부128례，안조시부합병고혈압분위임신기고혈압종합정조(60례)화정상임신조(68례)，령선택동기건강녀성70례작위대조조。대비3조혈장D-이취체수평。결과：임신고혈압조、정상임신조D-이취체수평현저고우대조조(P＜0.05，P＜0.01)。임신고혈압조D-이취체수평현저고우정상임신조(P＜0.05)；불동정도임신고혈압지간혈장D-이취체수평차이구유통계학의의(P＜0.05)。결론：정상임신자혈장D-이취체함량증고，혈액추우고응상태。임신고혈압질병환자반유응혈계통적병이학개변，기혈장D-이취체수평교정상임신경고。건의대임신고혈압환자진행엄격적혈장D-이취체수평감측，이급시료해시부존재혈전성병변，유효보호모영건강。
Objective:To analyze the difference of D-dimer level of normal pregnancy and pregnancy hypertension syndrome pregnant woman,and to explore the influence of hypertension on D-two dimer level of pregnant women.Methods:128 pregnant women were selected from March 2010 to October 2013.According to with hypertension or not,they were divided into the pregnancy induced hypertension syndrome group(60 cases) and the normal pregnancy group(68 cases),at the same time,70 healthy women were selected as the control group.We compared the plasma D-dimer level of the three groups.Results:The D-dimer level of pregnancy induced hypertension group and normal pregnancy group were significantly higher than those of the control group(P<0.05,P<0.01).The D-dimer level of pregnancy induced hypertension group were significantly higher than that of normal pregnancy group(P<0.05);between the different degree pregnancy induced hypertension,the plasma D-dimer level had significant difference(P<0.05).Conclusion:The plasma D-dimer content of normal pregnancy is increased,and the blood is become hypercoagulable state.Patients with hypertensive disorders in pregnancy have the pathological changes of the coagulation system,and the plasma D-dimer level is higher than that of normal pregnancy.We suggest that we should examine the plasma D-dimer level of patients with hypertension of pregnancy,and understand the existence of thrombotic diseases,to protect the health of mother and infant.