CAJ | 학술논문

目的：探讨2型糖尿病对结直肠癌患者临床病理特征和转移、预后的影响。方法收集708例结直肠癌患者临床资料和病理标本，按照静脉血糖水平分为2型糖尿病组（A组）和血糖正常组（B组），分别观察两组标本病理分化程度、浸润深度、TNM分期、淋巴结转移、远处转移和脉管癌栓；随访两组患者的生存时间。结果 A组为195人（27.5%），B组为513人（72.5%）；A组浸润深度、TNM分期、淋巴结转移、远处转移和脉管癌栓与B组相比均有明显，差异有统计学意义（P<0.05）；A组平均生存时间和5年生存率显著低于B组，差异有统计学意义（P<0.05)。结论2型糖尿病对结直肠癌侵袭和转移具有协同作用，降低患者的生存时间和生存率。
목적：탐토2형당뇨병대결직장암환자림상병리특정화전이、예후적영향。방법수집708례결직장암환자림상자료화병리표본，안조정맥혈당수평분위2형당뇨병조（A조）화혈당정상조（B조），분별관찰량조표본병리분화정도、침윤심도、TNM분기、림파결전이、원처전이화맥관암전；수방량조환자적생존시간。결과 A조위195인（27.5%），B조위513인（72.5%）；A조침윤심도、TNM분기、림파결전이、원처전이화맥관암전여B조상비균유명현，차이유통계학의의（P<0.05）；A조평균생존시간화5년생존솔현저저우B조，차이유통계학의의（P<0.05)。결론2형당뇨병대결직장암침습화전이구유협동작용，강저환자적생존시간화생존솔。
Objective To investigate the clinicopathological characteristics and prognosis of colorectal cancer patients complicated with type 2 diabetes mellitus. Methods The clinical data and pathological specimens of 708 cases of patients with colorectal can-cer were collected, and they were divided into type 2 diabetes mellitus group (group A) and normal blood glucose group (group B) according to venous blood glucose level. The pathological differentiation, depth of invasion, TNM stage, lymph node metastasis, distant metastasis and cancer embolus of two groups of specimens were observed respectively. The survival time of two groups of patients was followed up. Results The number of group A and group B was 195 (27.5%) and 513 (72.5%), respectively. Compared the depth of invasion, TNM stage, lymph node metastasis, distant metastasis and cancer embolus of group A with those of group B, the differences between the groups were statistically significant (P<0.05); the mean survival time and survival rate of 5 years of group A was significantly shorter than that of group B(P<0.05). Conclusion Type 2 diabetes mellitus has a synergistic effect on the invasion and metastasis of colorectal cancer, which can reduce the survival time and survival rate of the patients.