CAJ | 학술논문

目的：探讨分析羟乙基淀粉治疗小儿肾病综合征重度水肿的疗效及其安全性。方法将该院近5年收治的46例肾病综合征重度水肿患儿，采用随机分组方法分为试验组和对照组，试验组给予静脉滴注羟乙基淀粉加静脉注射呋塞米，对照组给予静脉滴注低分子右旋糖酐和静脉注射呋塞米。两组患者均治疗3 d，观察治疗过程中不良反应的发生情况和治疗效果，包括尿量、腹围、体重变化情况。结果治疗3d后，试验组尿量、腹围、体重改变情况明显优于对照组，差异有统计学意义；治疗过程中试验组不良反应发生率为4.3%，对照组为30.4%，两组比较，差异有统计学意义（P<0.05）。结论羟乙基淀粉治疗肾病综合征水肿疗效理想，不良反应少，安全性较好，值得推广。
목적：탐토분석간을기정분치료소인신병종합정중도수종적료효급기안전성。방법장해원근5년수치적46례신병종합정중도수종환인，채용수궤분조방법분위시험조화대조조，시험조급여정맥적주간을기정분가정맥주사부새미，대조조급여정맥적주저분자우선당항화정맥주사부새미。량조환자균치료3 d，관찰치료과정중불량반응적발생정황화치료효과，포괄뇨량、복위、체중변화정황。결과치료3d후，시험조뇨량、복위、체중개변정황명현우우대조조，차이유통계학의의；치료과정중시험조불량반응발생솔위4.3%，대조조위30.4%，량조비교，차이유통계학의의（P<0.05）。결론간을기정분치료신병종합정수종료효이상，불량반응소，안전성교호，치득추엄。
Objective To discuss and analyze the clinical effect and safety of hydroxyethyl starch for the treatment of severe edema of pediatric nephrotic syndrome. Methods 46 cases of severe edema of pediatric nephrotic syndrome admitted in our hospital in recent 5 years were randomly divided into experiment group and control group. Experiment group was given hydroxyethyl starch (i. v. drip) combined furosemide (i.v.) while control group was given low molecular dextran (i.v. drip) combined furosemide (i.v.). The treatment course of both groups was 3 days. The occurrence of adverse effects and clinical effects including the changes of urine volume, abdominal girth and weight were observed during the treatment course. Results After 3 days of treatment, the changes of urine volume, abdominal girth and weight of experiment group were obviously better than those of control group, the difference was statistically significant; the incidence of adverse reactions of experiment group was 4.3% and that of control group was 30.4%, the difference was statistically significant, P<0.05. Conclusion Hydroxyethyl starch for the treatment of edema of pediatric nephrotic syndrome has ideal clinical effect, few adverse reactions and high safety, so it's worth of being popularized.