CAJ | 학술논문

目的：研究并探讨益生菌在消化系肿瘤临床治疗中的潜在价值与效果。方法择取该院自2012年1月-2013年6月期间，住院部所收治胃癌患者共计50例为研究对象，随机分为对照组、干预组，每组25例。对照组常规治疗，干预组加双歧杆菌活菌肠溶胶囊治疗。对两组患者特异性组织学、免疫组化指标进行对比分析。结果干预组在益生菌干预下的微脓疡、纤维组织增生症状得到明显改善，优于对照组；癌组织微血管密度指标以及增值细胞核抗原指标均明显低于对照组，数据对比差异有统计学意义（P＜0.05）。结论双歧杆菌可抑制胃癌患者组织血管新生，改善缺血性问题，降低癌细胞增殖活性，效果突出。
목적：연구병탐토익생균재소화계종류림상치료중적잠재개치여효과。방법택취해원자2012년1월-2013년6월기간，주원부소수치위암환자공계50례위연구대상，수궤분위대조조、간예조，매조25례。대조조상규치료，간예조가쌍기간균활균장용효낭치료。대량조환자특이성조직학、면역조화지표진행대비분석。결과간예조재익생균간예하적미농양、섬유조직증생증상득도명현개선，우우대조조；암조직미혈관밀도지표이급증치세포핵항원지표균명현저우대조조，수거대비차이유통계학의의（P＜0.05）。결론쌍기간균가억제위암환자조직혈관신생，개선결혈성문제，강저암세포증식활성，효과돌출。
Objective To study and explore the potential value and effect of probiotics in the treatment of tumor of digestive sys-tem. Methods 50 patients with gastric cancer admitted in the in-patient department of our hospital from January 2012 to June 2013 were selected as the subjects and they were randomly divided into the control group and the intervention group with 25 cases in each. The control group was given the conventional treatment, and the intervention group was given the conventional treatment plus bifidobacterium enteric coated capsules. The specific histological and immunohistochemical indicators of these two groups were compared and analyzed. Results After the intervention of probiotics, the symptoms of microabscess and fibrous tissue hyper-plasia of the intervention group were improved significantly, which were better than those of the control group; carcinoma mi-crovessel density index and proliferating cell nuclear antigen indexes were obviously lower than those of the control group, there was a statistically significant difference in comparison of the data between the two groups (P<0.05). Conclusion Bifidobacterium has a prominent effect on prohibiting the tissue angiogenesis of patients with gastric cancer, improving the ischemic problems, and reducing the proliferation activity of cancer cells.