中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
21期
17-18
,共2页
p85α基因%卵巢癌%表达率%临床意义
p85α基因%卵巢癌%錶達率%臨床意義
p85α기인%란소암%표체솔%림상의의
p85αgene%Ovarian cancer%Expression rate%Clinical significance
目的：观察p85α基因在卵巢癌组织中的表达，探讨其与卵巢癌发生的关系及用于卵巢癌的早期诊断与治疗的临床意义。方法选取检测卵巢癌组织（66例）、癌旁组织（66例）及正常卵巢组织（17例）三个不同组织作为检测对象，采用免疫组化检测技术检测p85α基因表达产物及探讨p85α基因表达与卵巢癌临床特征的关系。结果 p85α基因在卵巢癌组织、癌旁组织、正常卵巢组织中的表达率分别为68.2%、59.1%、11.8%，即为该基因在卵巢癌组织中与癌旁组织、正常卵巢组织相比都较高，差异有统计学意义(P<0.05)，p85α基因表达与卵巢癌的发病年龄关系差异无统计学意义(P>0.05)，而与不同的临床分期、淋巴结的转移情况比较，差异有统计学意义(P<0.05)。结论 PI3K p85α基因的异常表达可以作为卵巢癌早期诊断和判断其生物学特性的指标。
目的：觀察p85α基因在卵巢癌組織中的錶達，探討其與卵巢癌髮生的關繫及用于卵巢癌的早期診斷與治療的臨床意義。方法選取檢測卵巢癌組織（66例）、癌徬組織（66例）及正常卵巢組織（17例）三箇不同組織作為檢測對象，採用免疫組化檢測技術檢測p85α基因錶達產物及探討p85α基因錶達與卵巢癌臨床特徵的關繫。結果 p85α基因在卵巢癌組織、癌徬組織、正常卵巢組織中的錶達率分彆為68.2%、59.1%、11.8%，即為該基因在卵巢癌組織中與癌徬組織、正常卵巢組織相比都較高，差異有統計學意義(P<0.05)，p85α基因錶達與卵巢癌的髮病年齡關繫差異無統計學意義(P>0.05)，而與不同的臨床分期、淋巴結的轉移情況比較，差異有統計學意義(P<0.05)。結論 PI3K p85α基因的異常錶達可以作為卵巢癌早期診斷和判斷其生物學特性的指標。
목적：관찰p85α기인재란소암조직중적표체，탐토기여란소암발생적관계급용우란소암적조기진단여치료적림상의의。방법선취검측란소암조직（66례）、암방조직（66례）급정상란소조직（17례）삼개불동조직작위검측대상，채용면역조화검측기술검측p85α기인표체산물급탐토p85α기인표체여란소암림상특정적관계。결과 p85α기인재란소암조직、암방조직、정상란소조직중적표체솔분별위68.2%、59.1%、11.8%，즉위해기인재란소암조직중여암방조직、정상란소조직상비도교고，차이유통계학의의(P<0.05)，p85α기인표체여란소암적발병년령관계차이무통계학의의(P>0.05)，이여불동적림상분기、림파결적전이정황비교，차이유통계학의의(P<0.05)。결론 PI3K p85α기인적이상표체가이작위란소암조기진단화판단기생물학특성적지표。
Objective To observe the expression of p85α gene in ovarian cancer tissues and explore its relationship with the oc-currence of ovarian cancer and its clinical significance for the early diagnosis and treatment of ovarian cancer. Methods We chose ovarian cancer tissues (66 cases), ovarian cancer adjacent tissues (66 cases) and normal ovarian tissues (17 cases), three different kinds of tissues as the detection objects. Immunohistochemical technique was used to detect p85α gene expression. The relation-ship between p85α gene expression and the clinical features of ovarian cancer was investigated. Results The expression rate of p85α gene in ovarian cancer tissues, ovarian adjacent cancer tissues and normal ovarian tissues was 68.2%, 59.1%, 11.8%, re-spectively, the expression rate of p85α gene in ovarian cancer tissues was higher than that in the ovarian adjacent cancer tissues and normal ovarian tissues, the difference was statistically significant (P<0.05);p85αgene expression had no significant correlation with the age of onset of ovarian cancer (P>0.05), but in clinical stage and lymph node metastasis there was statistical significance (P<0.05). Conclusion The abnormal expression of PI3K p85α genes can be used as the indicator for early diagnosis of ovarian cancer and determination of its biological characteristics.
