现代医药卫生
現代醫藥衛生
현대의약위생
MODERN MEDICINE HEALTH
2014年
16期
2422-2423,2426
,共3页
脑损伤/治疗%危重病%神经生长因子%鼠科%高压氧%干预性研究%婴儿
腦損傷/治療%危重病%神經生長因子%鼠科%高壓氧%榦預性研究%嬰兒
뇌손상/치료%위중병%신경생장인자%서과%고압양%간예성연구%영인
Brain injuries/therapy%Critical illness%Nerve growth factor%Muridae%Hyperbaric oxygenation%Intervention studies%Infant
目的：观察鼠神经生长因子（NGF）和高压氧治疗高危婴儿脑损伤的疗效，探讨高危婴儿脑损伤的治疗方法。方法对2010年1月至2013年12月在该院产科出生及儿童保健门诊就诊的92例0~1岁脑损伤高危婴儿进行早期干预治疗。根据不同治疗方案分为对照组28例、NGF组21例、高压氧组19例、NGF联合高压氧组24例。对照组仅给予一般治疗；NGF组在对照组治疗基础上加用NGF，用量为20μg/d，肌内注射，连用10 d，停用20 d为一疗程，连用5个疗程；高压氧组在对照组基础上给予高压氧治疗，压力为30.3~50.5 kPa，吸氧60 min，每天1次，10次为一疗程，停用20 d后重复，5个疗程；NGF联合高压氧组在对照组治疗基础上给予NGF联合高压氧治疗，方法同上。比较各组临床治疗效果。结果 NGF组、高压氧组、NGF联合高压氧组有效率均高于对照组，NGF联合高压氧组有效率高于NGF组、高压氧组，差异均有统计学意义（P<0.05或0.01）；NGF 组与高压氧组有效率比较，差异无统计学意义（P＞0.05）。结论NGF与高压氧的联合使用对高危婴儿脑损伤可增加干预效果。
目的：觀察鼠神經生長因子（NGF）和高壓氧治療高危嬰兒腦損傷的療效，探討高危嬰兒腦損傷的治療方法。方法對2010年1月至2013年12月在該院產科齣生及兒童保健門診就診的92例0~1歲腦損傷高危嬰兒進行早期榦預治療。根據不同治療方案分為對照組28例、NGF組21例、高壓氧組19例、NGF聯閤高壓氧組24例。對照組僅給予一般治療；NGF組在對照組治療基礎上加用NGF，用量為20μg/d，肌內註射，連用10 d，停用20 d為一療程，連用5箇療程；高壓氧組在對照組基礎上給予高壓氧治療，壓力為30.3~50.5 kPa，吸氧60 min，每天1次，10次為一療程，停用20 d後重複，5箇療程；NGF聯閤高壓氧組在對照組治療基礎上給予NGF聯閤高壓氧治療，方法同上。比較各組臨床治療效果。結果 NGF組、高壓氧組、NGF聯閤高壓氧組有效率均高于對照組，NGF聯閤高壓氧組有效率高于NGF組、高壓氧組，差異均有統計學意義（P<0.05或0.01）；NGF 組與高壓氧組有效率比較，差異無統計學意義（P＞0.05）。結論NGF與高壓氧的聯閤使用對高危嬰兒腦損傷可增加榦預效果。
목적：관찰서신경생장인자（NGF）화고압양치료고위영인뇌손상적료효，탐토고위영인뇌손상적치료방법。방법대2010년1월지2013년12월재해원산과출생급인동보건문진취진적92례0~1세뇌손상고위영인진행조기간예치료。근거불동치료방안분위대조조28례、NGF조21례、고압양조19례、NGF연합고압양조24례。대조조부급여일반치료；NGF조재대조조치료기출상가용NGF，용량위20μg/d，기내주사，련용10 d，정용20 d위일료정，련용5개료정；고압양조재대조조기출상급여고압양치료，압력위30.3~50.5 kPa，흡양60 min，매천1차，10차위일료정，정용20 d후중복，5개료정；NGF연합고압양조재대조조치료기출상급여NGF연합고압양치료，방법동상。비교각조림상치료효과。결과 NGF조、고압양조、NGF연합고압양조유효솔균고우대조조，NGF연합고압양조유효솔고우NGF조、고압양조，차이균유통계학의의（P<0.05혹0.01）；NGF 조여고압양조유효솔비교，차이무통계학의의（P＞0.05）。결론NGF여고압양적연합사용대고위영인뇌손상가증가간예효과。
Objective To observe the effects of mouse nerve growth factors (NGF)and high pressure oxygen (HPO) on brain damage in high-risk infants, and investigate the therapeutic method of brain damage. Methods A total of 92 high-risk in-fants with brain damage during 0-1 years old ,who were born in the Obstetrical Department or treated in Child Health Division in the hospital from January 2010 to December 2013 ,were treated with early intervention. According to the therapeutic schedule ,all the infants were divided into control group(n=28),NGF group(n=21),HPO group(n=19) and combination group of NGF and HPO (n=24). The control group only used general treatment;the NGF group was with intramuscular injection with 20μg/d mouse NGF on the basis of the control group for continuous 10 d ,discontinuation of 20 d was a period ,and 5 periods were necessary;the HPO group was added with HPO for treatment,with the pressure of 30.3-50.5 kPa,oxygen inhalation of 60 min,once every day,and 10 times was a course of treatment,5 courses were repeated after discontinuation of 20 d;the combination group was added with NGF associated with HPO on the basis of general treatment ,it was the same way as above. The clinical efficacy of the 4 groups were compared. Results The effective rate of NGF group,HPO group and combination group was higher than that of the control group,the effective rate of combination group was higher than that of the NGF group and HPO group,and the differences were sta-tistically significant(P<0.05 or 0.01),but the difference of effective rate between NGF group and HPO group had no statistical significance(P>0.05). Conclusion The application of mouse NGF associated with HPO can improve the intervention efficacy of brain damage in high-risk infants.
